Ki-67
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| Ki-67 | |
|---|---|
| Immunostain in short | |
 Ki-67 staining in an anaplastic astrocytoma. | |
| Use | typical carcinoid versus atypical carcinoid), grading (gastrointestinal neuroendocrine tumours) |
| Normal staining pattern | nuclear staining, occasionally membranous pattern (pneumocytoma, hyalinizing trabecular tumour) |
Ki-67 is a very commonly used immunostain that is reflective of proliferative activity.
MIB1 redirects here; it is a commonly used antibody against Ki-67.
General
- Marker of proliferation.
- Usually nuclear staining.
Membranous staining pattern
Ki-67 showing a membranous pattern in pneumocytoma.
- Pneumocytoma has membranous pattern.[1]
- Hyalinizing trabecular tumour - only with MIB1 antibody clone when processed at room temperature.[2]
See also
References
- ↑ Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.
- ↑ Leonardo, E.; Volante, M.; Barbareschi, M.; Cavazza, A.; Dei Tos, AP.; Bussolati, G.; Papotti, M. (Jun 2007). "Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?". Appl Immunohistochem Mol Morphol 15 (2): 220-3. doi:10.1097/01.pai.0000213122.66096.f0. PMID 17525638.