Hyalinizing trabecular tumour
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Hyalinizing trabecular tumour, abbreviated HTT, is a rare tumour of the thyroid gland. It is also known as hyalinizing trabecular adenoma.
General
- Considered by some to be a variant of papillary thyroid carcinoma.[1]
- Behaviour similar to papillary thyroid carcinoma - indolent.
Microscopic
Features:
- Trabecular arrangement of cells.
- May have "curved" trabeculae.
- Well defined cell borders.
- Extracellular space has hyaline material - key feature.
- Cytoplasm mimics hyaline material in the extracellular space.
DDx:
- Papillary thyroid carcinoma (if one believes this is a separate entity).
- Medullary thyroid carcinoma - not trabecular, nuclei not PTC-like.
- Paraganglioma.[2]
Images
HHT - low mag. (WC)
HHT - intermed. mag. (WC)
HHT - high mag. (WC)
Thyroid gland - high mag. (WC)
HHT - intermed. mag. (WC)
HHT - high mag. (WC)
HHT - intermed. mag. (WC)
HHT - high mag. (WC)
HHT - very high mag. (WC)
www:
IHC
- Thyroglobulin +ve.
- NSE +ve.
- Ki-67 - may have membranous pattern.[5]
Molecular
- GLIS rearrangement (PAX8-GLIS3, PAX8-GLIS1).[6]
See also
References
- ↑ Cheung CC, Boerner SL, MacMillan CM, Ramyar L, Asa SL (December 2000). "Hyalinizing trabecular tumor of the thyroid: a variant of papillary carcinoma proved by molecular genetics". Am. J. Surg. Pathol. 24 (12): 1622–6. PMID 11117782.
- ↑ URL: http://path.upmc.edu/cases/case465/dx.html. Accessed on: 17 January 2011.
- ↑ Baloch, ZW.; Puttaswamy, K.; Brose, M.; LiVolsi, VA. (2006). "Lack of BRAF mutations in hyalinizing trabecular neoplasm.". Cytojournal 3: 17. doi:10.1186/1742-6413-3-17. PMID 16867191.
- ↑ URL: http://www.ispub.com/journal/the-internet-journal-of-endocrinology/volume-2-number-1/hyalinizing-trabecular-neoplasm-of-the-thyroid-controversies-in-management.html. Accessed on: 1 January 2012.
- ↑ Leonardo, E.; Volante, M.; Barbareschi, M.; Cavazza, A.; Dei Tos, AP.; Bussolati, G.; Papotti, M. (Jun 2007). "Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?". Appl Immunohistochem Mol Morphol 15 (2): 220-3. doi:10.1097/01.pai.0000213122.66096.f0. PMID 17525638.
- ↑ Nikiforova, MN.; Nikitski, AV.; Panebianco, F.; Kaya, C.; Yip, L.; Williams, M.; Chiosea, SI.; Seethala, RR. et al. (Feb 2019). "GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland.". Thyroid 29 (2): 161-173. doi:10.1089/thy.2018.0791. PMID 30648929.