Difference between revisions of "Xanthogranulomatous pyelonephritis"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Xanthogranulomatous_pyelonephritis_cd68.jpg
| Width      =
| Caption    = Xanthogranulomatous pyelonephritis. CD68 immunostain.
| Synonyms  =
| Micro      = abundant (foamy) macrophages (associated with the collecting system - medulla, not cortex), +/-giant cells, +/-cholesterol clefts, +/-interstitial lymphocytes and plasma cells, +/-interstitial fibrosis, +/-calcifications
| Subtypes  =
| LMDDx      = [[malakoplakia]], RCC - especially [[PRCC]], granulomatous disease, [[chronic pyelonephritis]], interstitial nephritis, occasionally [[renal cell carcinoma]]
| Stains    = [[PAS-D]] -ve
| IHC        = CD68 +ve, CD10 -ve, [[pankeratin]] -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[kidney]] - see ''[[kidney tumours]]''
| Assdx      = [[diabetes mellitus]], history of UTI, [[nephrolithiasis]], GU obstruction (various causes)
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      = dilated upper GU system
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = [[renal cell carcinoma]], [[pyelonephritis]]
| Tx        = antibiotics, occasionally nephrectomy
}}
'''Xanthogranulomatous pyelonephritis''', abbreviated '''XGP''', is an inflammatory process of the [[kidney]] that can mimic [[renal cell carcinoma]].
'''Xanthogranulomatous pyelonephritis''', abbreviated '''XGP''', is an inflammatory process of the [[kidney]] that can mimic [[renal cell carcinoma]].


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*Associated with:  
*Associated with:  
**[[Diabetes mellitus]].  
**[[Diabetes mellitus]].  
**History of UTI.<ref name=pmid17987581>{{cite journal |author=Afgan F, Mumtaz S, Ather MH |title=Preoperative diagnosis of xanthogranulomatous pyelonephritis |journal=Urol J |volume=4 |issue=3 |pages=169–73 |year=2007 |pmid=17987581 |doi= |url=}}</ref>
**History of [[urinary tract infection]].<ref name=pmid17987581>{{cite journal |author=Afgan F, Mumtaz S, Ather MH |title=Preoperative diagnosis of xanthogranulomatous pyelonephritis |journal=Urol J |volume=4 |issue=3 |pages=169–73 |year=2007 |pmid=17987581 |doi= |url=}}</ref>
**Nephrolithiasis.
**[[Nephrolithiasis]].
**GU obstruction.<ref name=pmid17098659>{{cite journal |author=Al-Ghazo MA, Ghalayini IF, Matalka II, Al-Kaisi NS, Khader YS |title=Xanthogranulomatous pyelonephritis: Analysis of 18 cases |journal=Asian J Surg |volume=29 |issue=4 |pages=257–61 |year=2006 |month=October |pmid=17098659 |doi= |url=}}</ref>
**GU obstruction.<ref name=pmid17098659>{{cite journal |author=Al-Ghazo MA, Ghalayini IF, Matalka II, Al-Kaisi NS, Khader YS |title=Xanthogranulomatous pyelonephritis: Analysis of 18 cases |journal=Asian J Surg |volume=29 |issue=4 |pages=257–61 |year=2006 |month=October |pmid=17098659 |doi= |url=}}</ref>
*Occasionally an indication of nephrectomy.<ref name=pmid17987581/><ref name=pmid17098659/>
*Occasionally an indication for nephrectomy.<ref name=pmid17987581/><ref name=pmid17098659/>
*Most common organism (in the context of nephrectomy specimens) - ''Proteus mirabilis''.<ref name=pmid17098659/>
*Most common organism (in the context of nephrectomy specimens) - ''Proteus mirabilis''.<ref name=pmid17098659/>


==Microscopic==
==Microscopic==
*Abundant macrophages.
Features:
*Abundant (foamy) macrophages.
**Associated with the collecting system - medulla, not cortex.
*+/-Giant cells.
*+/-Giant cells.
*+/-Interstitial lymphocytes and plasma cells.
*+/-Interstitial fibrosis.
*+/-Cholesterol clefts (common).
*+/-Calcifications - dystrophic.


DDx:  
DDx:  
*[[Malakoplakia]].  
*[[Malakoplakia]].  
**Basophilic inclusions -- inside or outside of macrophages - often size of RBC or larger ([[Michaelis-Gutmann bodies]]).
**Basophilic inclusions -- inside or outside of macrophages - often size of RBC or larger ([[Michaelis-Gutmann bodies]]).
*RCC - especially [[PRCC]] (as this has foamy macrophages).
*[[Renal cell carcinoma]] - especially [[papillary RCC]] (as this has foamy macrophages).
*Granulomatous disease.
*[[Granulomatous disease]].
*[[Chronic pyelonephritis]].
*[[Chronic pyelonephritis]].
*[[Interstitial nephritis]].
*[[Interstitial nephritis]].
 
*[[Renal cell carcinoma]] - foamy macrophages may be abundant.<ref name=pmid8378177>{{Cite journal  | last1 = Iskandar | first1 = SS. | last2 = Prahlow | first2 = JA. | last3 = White | first3 = WL. | title = Lipid-laden foamy macrophages in renal cell carcinoma. Potential frozen section diagnostic pitfall. | journal = Pathol Res Pract | volume = 189 | issue = 5 | pages = 549-52 | month = Jun | year = 1993 | doi = 10.1016/S0344-0338(11)80364-X | PMID = 8378177 }}</ref>
===Image===
===Images===
<gallery>
<gallery>
Image:Xanthogranulomatous_pyelonephritis_cd68.jpg | Xanthogranulomatous pyelonephritis - CD68 stain. (WC/Nephron)
Image:Xanthogranulomatous_pyelonephritis_cd68.jpg | Xanthogranulomatous pyelonephritis - CD68 stain. (WC/Nephron)
</gallery>
</gallery>
www:
*[http://www.archivesofpathology.org/na101/home/literatum/publisher/pinnacle/journals/content/arpa/2011/15432165-135.5/2009-0769-rsr.1/production/images/large/i1543-2165-135-5-671-f01.jpeg Several images of XGP (archivesofpathology.org)].<ref name=pmid21526966>{{Cite journal  | last1 = Li | first1 = L. | last2 = Parwani | first2 = AV. | title = Xanthogranulomatous pyelonephritis. | journal = Arch Pathol Lab Med | volume = 135 | issue = 5 | pages = 671-4 | month = May | year = 2011 | doi = 10.1043/2009-0769-RSR.1 | PMID = 21526966 }}</ref>


==Stains==
==Stains==
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- CHRONIC INTERSTITIAL NEPHRITIS.
- CHRONIC INTERSTITIAL NEPHRITIS.
- INCREASED NUMBERS OF TOTALLY SCLEROSED GLOMERULI AND GLOMERULI WITH FOCAL  
- INCREASED NUMBERS OF TOTALLY SCLEROSED GLOMERULI AND GLOMERULI WITH FOCAL  
   SEGMENTAL GLOMERULOSCLEROSIS.
   SCLEROSIS.
- MARKED INTERSTITIAL FIBROSIS.
- MARKED INTERSTITIAL FIBROSIS.
- NEGATIVE FOR MALIGNANCY.
- NEGATIVE FOR MALIGNANCY.
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immunostain.  
immunostain.  
</pre>
</pre>
===Micro===
The sections show degenerative renal parenchyma with surrounding histiocytes, other inflammatory cells, fibrosis and cholesterol clefts.


==See also==
==See also==
*[[Kidney tumours]].
*[[Kidney tumours]].
*[[Acute pyelonephritis]].
*[[Xanthogranulomatous cystitis]].


==References==
==References==

Latest revision as of 02:38, 22 February 2017

Xanthogranulomatous pyelonephritis
Diagnosis in short

Xanthogranulomatous pyelonephritis. CD68 immunostain.

LM abundant (foamy) macrophages (associated with the collecting system - medulla, not cortex), +/-giant cells, +/-cholesterol clefts, +/-interstitial lymphocytes and plasma cells, +/-interstitial fibrosis, +/-calcifications
LM DDx malakoplakia, RCC - especially PRCC, granulomatous disease, chronic pyelonephritis, interstitial nephritis, occasionally renal cell carcinoma
Stains PAS-D -ve
IHC CD68 +ve, CD10 -ve, pankeratin -ve
Site kidney - see kidney tumours

Associated Dx diabetes mellitus, history of UTI, nephrolithiasis, GU obstruction (various causes)
Prevalence uncommon
Radiology dilated upper GU system
Clin. DDx renal cell carcinoma, pyelonephritis
Treatment antibiotics, occasionally nephrectomy

Xanthogranulomatous pyelonephritis, abbreviated XGP, is an inflammatory process of the kidney that can mimic renal cell carcinoma.

General

Microscopic

Features:

  • Abundant (foamy) macrophages.
    • Associated with the collecting system - medulla, not cortex.
  • +/-Giant cells.
  • +/-Interstitial lymphocytes and plasma cells.
  • +/-Interstitial fibrosis.
  • +/-Cholesterol clefts (common).
  • +/-Calcifications - dystrophic.

DDx:

Images

www:

Stains

  • PAS-D -ve.
    • Done to look for malakoplakia.

IHC

  • CD68 +ve.
  • RCC markers (CD10, RCC) all negative.

Sign out

RIGHT KIDNEY, NEPHRECTOMY:
- XANTHOGRANULOMATOUS PYELONEPHRITIS.
- CHRONIC INTERSTITIAL NEPHRITIS.
- INCREASED NUMBERS OF TOTALLY SCLEROSED GLOMERULI AND GLOMERULI WITH FOCAL 
  SCLEROSIS.
- MARKED INTERSTITIAL FIBROSIS.
- NEGATIVE FOR MALIGNANCY.

COMMENT:
Immunostaining demonstrates abundant CD68 positive cells (macrophages).  A CD10 immunostain 
is non-concerning (it highlights glomeruli). A pankeratin immunostain is non-concerning 
(it highlights benign renal tubules).

Compatible XGP

"KIDNEY" LESION, LEFT, BIOPSY:
- FIBROMUSCULAR TISSUE WITH A MIXED INFLAMMATORY INFILTRATE.
- CELLULAR DEBRIS WITH SURROUNDING LOOSELY AGGREGATED HISTIOCYTES.
- NO RENAL PARENCHYMA IDENTIFIED.
- NEGATIVE FOR MALIGNANCY.

COMMENT:
A SMA immunostain highlights the muscle component, and a CD68 immunostain marks 
abundant histiocytes. No epithelial component is identified with a pankeratin 
immunostain. 

Micro

The sections show degenerative renal parenchyma with surrounding histiocytes, other inflammatory cells, fibrosis and cholesterol clefts.

See also

References

  1. 1.0 1.1 Afgan F, Mumtaz S, Ather MH (2007). "Preoperative diagnosis of xanthogranulomatous pyelonephritis". Urol J 4 (3): 169–73. PMID 17987581.
  2. 2.0 2.1 2.2 Al-Ghazo MA, Ghalayini IF, Matalka II, Al-Kaisi NS, Khader YS (October 2006). "Xanthogranulomatous pyelonephritis: Analysis of 18 cases". Asian J Surg 29 (4): 257–61. PMID 17098659.
  3. Iskandar, SS.; Prahlow, JA.; White, WL. (Jun 1993). "Lipid-laden foamy macrophages in renal cell carcinoma. Potential frozen section diagnostic pitfall.". Pathol Res Pract 189 (5): 549-52. doi:10.1016/S0344-0338(11)80364-X. PMID 8378177.
  4. Li, L.; Parwani, AV. (May 2011). "Xanthogranulomatous pyelonephritis.". Arch Pathol Lab Med 135 (5): 671-4. doi:10.1043/2009-0769-RSR.1. PMID 21526966.