Difference between revisions of "Small cell carcinoma of the lung"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Synonyms  =
| Micro      = stippled chromatin, high [[NC ratio]] with scant basophilic cytoplasm, typically small cells (~2x [[RBC]] diameter), +/-nuclear moulding, smudgy appearance [[Azzopardi phenonmenon]], necrosis, [[mitoses]]
| Subtypes  =
| LMDDx      =
| Stains    = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      =
| Assdx      =
| Syndromes  =
| Clinicalhx = [[smoking]] - usually a long history, heavy
| Signs      =
| Symptoms  =
| Prevalence = not common
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor
| Other      =
| ClinDDx    = other lung tumours ([[squamous cell carcinoma of the lung]]), metastatic tumours
| Tx        = medical (chemotherapy)
}
'''Small cell carcinoma of the lung''', also '''small cell lung carcinoma''' (abbreviated '''SCLC''')<ref name=pmid20943645/> is an aggressive [[malignant]] [[Lung tumours|tumour of the lung]]. It is strongly associated with [[smoking]].
'''Small cell carcinoma of the lung''', also '''small cell lung carcinoma''' (abbreviated '''SCLC''')<ref name=pmid20943645/> is an aggressive [[malignant]] [[Lung tumours|tumour of the lung]]. It is strongly associated with [[smoking]].


Revision as of 14:09, 5 January 2014

{{ Infobox diagnosis | Name = Small cell carcinoma of the lung | Image = | Width = | Caption = | Synonyms = | Micro = stippled chromatin, high NC ratio with scant basophilic cytoplasm, typically small cells (~2x RBC diameter), +/-nuclear moulding, smudgy appearance Azzopardi phenonmenon, necrosis, mitoses | Subtypes = | LMDDx = | Stains = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve | IHC = | EM = | Molecular = | IF = | Gross = | Grossing = | Site = | Assdx = | Syndromes = | Clinicalhx = smoking - usually a long history, heavy | Signs = | Symptoms = | Prevalence = not common | Bloodwork = | Rads = | Endoscopy = | Prognosis = poor | Other = | ClinDDx = other lung tumours (squamous cell carcinoma of the lung), metastatic tumours | Tx = medical (chemotherapy) } Small cell carcinoma of the lung, also small cell lung carcinoma (abbreviated SCLC)[1] is an aggressive malignant tumour of the lung. It is strongly associated with smoking.

General

  • Strong association with smoking.
  • Typically treated with chemotherapy.
  • Poor prognosis.

On a spectrum of lesions (benign to malignant):[1]

Precursor lesion - uncommonly seen:

  • Pulmonary neuroendocrine cell hyperplasia.[1]

Gross

  • Central location (close to large airways) - typical.
  • Necrosis.

Microscopic

Features:

  • Stippled chromatin.
  • High NC ratio, scant basophilic cytoplasm.
  • Typically small cells ~2x RBC diameter.
  • +/-Nuclear moulding.
  • Necrosis.
  • Mitoses.

Notes:

  • There should be no nucleolus.

DDx:

Images

  • SCLC - low mag. (WC)

  • SCLC - high mag. (WC)

IHC

  • Synaptophysin +ve.
    • May be very weak.
  • TTF-1 +ve (15 of 16 cases).[2]

Sign out

LOWER LOBE OF LUNG, LEFT, CORE BIOPSY:
- SMALL CELL CARCINOMA.

See also

References

  1. ↑ 1.0 1.1 1.2 Travis, WD. (Oct 2010). "Advances in neuroendocrine lung tumors.". Ann Oncol 21 Suppl 7: vii65-71. doi:10.1093/annonc/mdq380. PMID 20943645.
  2. ↑ Wu, M.; Szporn, AH.; Zhang, D.; Wasserman, P.; Gan, L.; Miller, L.; Burstein, DE. (Oct 2005). "Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers.". Diagn Cytopathol 33 (4): 223-7. doi:10.1002/dc.20337. PMID 16138374.
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