Difference between revisions of "Sertoli cell tumour"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      = Sertoli_cell_tumour_high_mag.jpg
| Image      = Sertoli_cell_tumour_high_mag.jpg  
| Width      =
| Width      =
| Caption    = Sertoli cell tumour. [[H&E stain]].
| Caption    = Sertoli cell tumour. [[H&E stain]].
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| LMDDx      =  [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]]
| LMDDx      =  [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]]
| Stains    =
| Stains    =
| IHC        = alpha-inhibin, calretinin
| IHC        = [[SF-1]] +ve, alpha-inhibin +ve, calretinin +ve/-ve,
| EM        =
| EM        =
| Molecular  =
| Molecular  =
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==IHC==
==IHC==
*Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>).
*Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>).
*Calretiin +ve (~55% of cases<ref name=pmid17721194/>).
*[[Calretinin]] +ve (~55% of cases<ref name=pmid17721194/>).
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref>
**Negative beta-catenin should make one consider other diagnoses.{{fact}}
**May be negative in malignant sertoli cell tumours.
*[[SF-1]] +ve.<ref name=pmid23165333>{{cite journal |authors=Sangoi AR, McKenney JK, Brooks JD, Higgins JP |title=Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases |journal=Appl Immunohistochem Mol Morphol |volume=21 |issue=4 |pages=318–21 |date=July 2013 |pmid=23165333 |doi=10.1097/PAI.0b013e318277cf5a |url=}}</ref>
**Germ cell tumours -ve.


Others:
Others:
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*[[Leydig cell tumour]].
*[[Leydig cell tumour]].
*[[Sertoli-Leydig tumour]].
*[[Sertoli-Leydig tumour]].
*[[Sex cord-stromal tumours]]
*[[Testis]].
*[[Testis]].



Latest revision as of 15:02, 18 April 2024

Sertoli cell tumour
Diagnosis in short

Sertoli cell tumour. H&E stain.

LM groups of cells in cords or trabeculae, cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin
LM DDx granulosa cell tumour, epithelioid adenomatoid tumour, sertoli cell nodule, Sertoli-Leydig tumour
IHC SF-1 +ve, alpha-inhibin +ve, calretinin +ve/-ve,
Site testis, ovary

Syndromes Peutz-Jeghers syndrome, Carney complex

Signs testicular mass
Prevalence uncommon

Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis. It is occasionally seen in women.

General

  • Arises from Sertoli cells (AKA nurse cells).
  • Occasionally seen in women.[1]

May be seen in several syndrome - esp. if there is calcification:

Microscopic

Features:

  • Groups of cells in cords or trabeculae (beam-like arrangement).
  • Cells have:
    • Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
    • Slightly irregular nucleoli.
    • Granular irregular appearing chromatin.

Negatives:

  • Mitoses are rare.
  • No significant nuclear atypia.

DDx:

Images

www:

IHC

  • Alpha-inhibin +ve (~95% of cases[4]).
  • Calretinin +ve (~55% of cases[4]).
  • Beta-catenin +ve (nuclear).[5]
    • Negative beta-catenin should make one consider other diagnoses.[citation needed]
    • May be negative in malignant sertoli cell tumours.
  • SF-1 +ve.[6]
    • Germ cell tumours -ve.

Others:

See also

References

  1. Zizi-Sermpetzoglou, A.; Petrakopoulou, N.; Tepelenis, N.; Savvaidou, V.; Manoloudaki, K.; Katsoulis, M. (2010). "Pure Sertoli cell tumor. a case report and review of the literature.". Eur J Gynaecol Oncol 31 (1): 117-9. PMID 20349797.
  2. Libé, R.; Horvath, A.; Vezzosi, D.; Fratticci, A.; Coste, J.; Perlemoine, K.; Ragazzon, B.; Guillaud-Bataille, M. et al. (Jan 2011). "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.". J Clin Endocrinol Metab 96 (1): E208-14. doi:10.1210/jc.2010-1704. PMID 21047926.
  3. Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.
  4. 4.0 4.1 4.2 Zhao, C.; Bratthauer, GL.; Barner, R.; Vang, R. (Sep 2007). "Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.". Am J Surg Pathol 31 (9): 1378-86. doi:10.1097/PAS.0b013e3180339961. PMID 17721194.
  5. Zhang C, Ulbright TM (October 2015). "Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases". Am J Surg Pathol 39 (10): 1390–4. doi:10.1097/PAS.0000000000000455. PMID 26034868.
  6. Sangoi AR, McKenney JK, Brooks JD, Higgins JP (July 2013). "Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases". Appl Immunohistochem Mol Morphol 21 (4): 318–21. doi:10.1097/PAI.0b013e318277cf5a. PMID 23165333.