Lymphocytic mastitis

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Lymphocytic mastitis is a rare pathology of the breast.

Lymphocytic mastitis
Diagnosis in short

LM lymphocytic infiltrates (breast lobules, perivascular), enlarged stromal fibroblasts, stromal collagen with keloid-like changes.
LM DDx lymphoma (small cell), diabetic mastopathy (need history)
IHC CD20 > CD3, CD43 -ve
Molecular negative for clonality
Site breast

Associated Dx +/-diabetes mellitus (known as diabetic mastopathy)
Prevalence rare
Prognosis benign

General

Microscopic

Features:[2]

  • Lymphocytic infiltrates - key feature:
    • Lobules.
    • Perivascular.
  • Enlarged stromal fibroblasts.
  • Stromal collagen with keloid-like changes.

DDx:

  • Diabetic mastopathy - if individual has diabetes.
  • Primary lymphoma of the breast.

Images

www:

IHC

  • B cell predominant (CD20 > CD3).[1]
    • B cells CD43 -ve.

Molecular

  • Negative clonality studies.

See also

References

  1. 1.0 1.1 Valdez, R.; Thorson, J.; Finn, WG.; Schnitzer, B.; Kleer, CG. (Mar 2003). "Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases.". Mod Pathol 16 (3): 223-8. doi:10.1097/01.MP.0000056627.21128.74. PMID 12640102.
  2. URL: http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html. Accessed on: 28 November 2010.