Difference between revisions of "Lymphocytic mastitis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = lymphocytic infiltrates (breast lobules, perivascular), enlarged stromal fibroblasts, stromal collagen with keloid-like changes. | |||
| Subtypes = | |||
| LMDDx = [[lymphoma]] ([[small cell lymphomas|small cell]]), diabetic mastopathy (need history) | |||
| Stains = | |||
| IHC = CD20 > CD3, CD43 -ve | |||
| EM = | |||
| Molecular = negative for clonality | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[breast]] | |||
| Assdx = +/-[[diabetes mellitus]] (known as [[diabetic mastopathy]]) | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Lymphocytic mastitis''' is a rare pathology of the [[breast]]. | '''Lymphocytic mastitis''' is a rare pathology of the [[breast]]. | ||
Revision as of 04:45, 16 February 2014
| Lymphocytic mastitis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | lymphocytic infiltrates (breast lobules, perivascular), enlarged stromal fibroblasts, stromal collagen with keloid-like changes. |
| LM DDx | lymphoma (small cell), diabetic mastopathy (need history) |
| IHC | CD20 > CD3, CD43 -ve |
| Molecular | negative for clonality |
| Site | breast |
|
| |
| Associated Dx | +/-diabetes mellitus (known as diabetic mastopathy) |
| Prevalence | rare |
| Prognosis | benign |
Lymphocytic mastitis is a rare pathology of the breast.
General
- If the individual has diabetes mellitus (DM) it is called diabetic mastopathy.[1]
- Rare.
Microscopic
Features:[2]
- Lymphocytic infiltrates - key feature:
- Lobules.
- Perivascular.
- Enlarged stromal fibroblasts.
- Stromal collagen with keloid-like changes.
DDx:
- Diabetic mastopathy - if individual has diabetes.
- Primary lymphoma of the breast.
Images
www:
- Lymphocytic mastitis - low mag. (webpathology.com).
- Lymphocytic mastitis - high mag. (webpathology.com).
IHC
- B cell predominant (CD20 > CD3).[1]
- B cells CD43 -ve.
Molecular
- Negative clonality studies.
See also
References
- ↑ 1.0 1.1 Valdez, R.; Thorson, J.; Finn, WG.; Schnitzer, B.; Kleer, CG. (Mar 2003). "Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases.". Mod Pathol 16 (3): 223-8. doi:10.1097/01.MP.0000056627.21128.74. PMID 12640102.
- ↑ URL: http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html. Accessed on: 28 November 2010.