Difference between revisions of "Invasive breast cancer"

Invasive breast cancer (view source)

619 bytes removed , 10:15, 14 February 2014

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 *[[AKA]] "NST" = No Specific Type.
 *[[AKA]] ''invasive mammary carcinoma''.
-===General===
+{{Main|Invasive ductal carcinoma of the breast}}
-*Most common type of invasive breast cancer.
-===Microscopic===
-Features:
-*Atypical cells:
-**Usually >2x RBC diameter.
-**Nucleoli common.
-**Forming ducts ''or'' sheets.
-**+/-Mitoses.
-**+/-Necrosis.
-*Evidence of invasion:
-**Atypical nucleus adjacent to adipocyte - '''diagnostic'''.
-**"Infiltrative" pattern:
-***Small glands of variable size within desmoplastic stroma.
-***Glands lined by a single layer of cells.
-DDx:
-*[[DCIS]].
-*[[Invasive lobular carcinoma]].
-===IHC===
-Myoepithelial markers - '''diagnostic''' for invasion:
-*SMMS -ve.
-*p63 -ve.
-Prognostic markers - may be useful for metastates:
-*ER +ve (diffuse).
-*PR +ve (diffuse).
-*HER2 -ve.
 ==Invasive lobular carcinoma==