Difference between revisions of "Invasive breast cancer"

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Invasive breast cancer (view source)

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→‎Mucinous breast carcinoma: split out
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==Mucinous breast carcinoma==
==Mucinous breast carcinoma==
*[[AKA]] ''mucinous carcinoma of the breast'', [[AKA]] ''colloid carcinoma of the breast''.
*[[AKA]] ''mucinous carcinoma of the breast'', [[AKA]] ''colloid carcinoma of the breast''.
 
{{Main|Mucinous breast carcinoma}}
===General===
*Rare.
*Good prognosis.<ref name=pmid18809061>{{Cite journal  | last1 = Barkley | first1 = CR. | last2 = Ligibel | first2 = JA. | last3 = Wong | first3 = JS. | last4 = Lipsitz | first4 = S. | last5 = Smith | first5 = BL. | last6 = Golshan | first6 = M. | title = Mucinous breast carcinoma: a large contemporary series. | journal = Am J Surg | volume = 196 | issue = 4 | pages = 549-51 | month = Oct | year = 2008 | doi = 10.1016/j.amjsurg.2008.06.013 | PMID = 18809061 }}</ref>
*Usually older women.
 
===Gross===
*Pale, glistening, jelly-like appearance.
*Well-circumscribed.
 
Image:
*[http://www.webpathology.com/image.asp?case=297&n=1 Mucinous carcinoma of the breast (webpathology.com)].
 
===Microscopic===
Features:
*Malignant mucin producing glands.
**Mucinous component must comprise >90% of the tumour - '''required for diagnosis'''.<ref name=pmid22006768>{{Cite journal  | last1 = Dogan | first1 = E. | last2 = Aksoy | first2 = S. | last3 = Dizdar | first3 = O. | last4 = Arslan | first4 = C. | last5 = Dede | first5 = DS. | last6 = Ozisik | first6 = Y. | last7 = Altundag | first7 = K. | title = Pure mucinous carcinoma of the breast: a single center experience. | journal = J BUON | volume = 16 | issue = 3 | pages = 565-7 | month =  | year =  | doi =  | PMID = 22006768 }}</ref>
**Cells should float in the mucin - '''key feature'''.
**Glands typically have irregular edges.
**+/-Vessels within the mucin pools.
 
DDx:
*[[DCIS]] with a mucinous component.
**Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.
 
Note:
*The amount of mucinous component to call ''[[mucinous carcinoma]]'' varies by anatomical site.
*All mucinous lesions should be excised.<ref name=pmid12218567>{{Cite journal  | last1 = Jacobs | first1 = TW. | last2 = Connolly | first2 = JL. | last3 = Schnitt | first3 = SJ. | title = Nonmalignant lesions in breast core needle biopsies: to excise or not to excise? | journal = Am J Surg Pathol | volume = 26 | issue = 9 | pages = 1095-110 | month = Sep | year = 2002 | doi =  | PMID = 12218567 }}</ref>
 
===IHC===
*ER +ve.
*PR +ve.
*HER2 -ve.


==Adenoid cystic carcinoma of the breast==
==Adenoid cystic carcinoma of the breast==
Michael
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