Difference between revisions of "Invasive breast cancer"

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Invasive breast cancer (view source)

Revision as of 10:40, 14 February 2014

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→‎Invasive lobular carcinoma
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*Abbreviated ''ILC''.
*Abbreviated ''ILC''.
*[[AKA]] ''lobular carcinoma''.
*[[AKA]] ''lobular carcinoma''.
===General===
{{Main|Invasive lobular carcinoma}}
*May be associated with a CDH1 mutation - seen in diffuse type [[stomach|gastric]] cancer.<ref>URL: [http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006 http://www.asco.org/ascov2/Meetings/Abstracts?&vmview=abst_detail_view&confID=65&abstractID=33006]. Accessed on: 19 April 2011.</ref><ref name=omim192090>{{OMIM|192090}}</ref>
 
===Microscopic===
Features:
*"Single file" - cell line-up in a row.
**Cell should not be cohesive -- [[lymphoma]] should briefly come to mind.
***primary lymphoma of the breast exists... but it is extremely rare.
*NO gland formation.
**If it forms glands... it is more likely NST.
*May have [[signet ring cell|signet ring]] morphology.
*NO [[desmoplastic reaction]], i.e. the stroma surrounding the tumour cells should look benign and undisturbed.
 
Note:
*Commonly have low grade nuclear features.
 
====Images====
<gallery>
Image:Lobular_carcinoma_-_low_mag.jpg | Lobular carcinoma - low mag. (WC/Nephron)
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - high mag. (WC/Nephron)
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - very high mag. (WC/Nephron)
</gallery>
 
More [[WC]] images:
*[http://commons.wikimedia.org/wiki/File:Breast_invasive_lobular_carcinoma_%281%29.jpg Lobular carcinoma - 1 (WC)].
*[http://commons.wikimedia.org/wiki/File:Breast_invasive_lobular_carcinoma_%282%29.jpg Lobular carcinoma - 2 (WC)].
 
====Subclassification====
*Classic lobular carcinoma.
**Low nuclear grade - NO significant variation of nucleus size.
*Pleomorphic lobular carcinoma.
**Significant nuclear atypia.
 
Note:
*Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."<ref>MUA. Jan 22, 2009.</ref>


==Medullary breast carcinoma==
==Medullary breast carcinoma==
Michael
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