Difference between revisions of "Human papillomavirus-related multiphenotypic sinonasal carcinoma"
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*Very rare diagnosis - recently described.<ref>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref> | *Very rare diagnosis - recently described.<ref>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Ogawa | first2 = T. | last3 = Stelow | first3 = EB. | last4 = Moskaluk | first4 = CA. | last5 = Koch | first5 = WM. | last6 = Pai | first6 = SI. | last7 = Westra | first7 = WH. | title = Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. | journal = Am J Surg Pathol | volume = 37 | issue = 6 | pages = 836-44 | month = Jun | year = 2013 | doi = 10.1097/PAS.0b013e31827b1cd6 | PMID = 23598962 }}</ref> | ||
*Associated with [[human papillomavirus]] (HPV). | *Associated with [[human papillomavirus]] (HPV). | ||
*An analogous tumour has been described in the [[breast pathology|breast]].<ref name=pmid33218360>{{cite journal |authors=Oramas DM, Bell D, Middleton LP |title=Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast |journal=Diagn Pathol |volume=15 |issue=1 |pages=137 |date=November 2020 |pmid=33218360 |pmc=7678216 |doi=10.1186/s13000-020-01050-7 |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Revision as of 16:17, 14 November 2021
Human papillomavirus-related multiphenotypic sinonasal carcinoma, abbreviated HPV-related multiphenotypic sinonasal carcinoma, is a rare malignant tumour of the head and neck.[1]
It is also known as human papillomavirus-related carcinoma with adenoid cystic-like features (abbreviated HPV-related carcinoma with AdCC-like features).[2]
General
- Very rare diagnosis - recently described.[3]
- Associated with human papillomavirus (HPV).
- An analogous tumour has been described in the breast.[4]
Microscopic
Features:
- Adenoid cystic carcinoma-like morphology with:
- Squamous dysplasia of surface epithelium.
- Squamous differentiation within tumour.
Notes:
- Perineural invasion rare.
- Bony invasion rare.
DDx:
- Adenoid cystic carcinoma.
- Basaloid squamous cell carcinoma.
IHC
- p16 +ve in >= 75% of cells.[5]
See also
References
- ↑ Bishop, JA.; Andreasen, S.; Hang, JF.; Bullock, MJ.; Chen, TY.; Franchi, A.; Garcia, JJ.; Gnepp, DR. et al. (Dec 2017). "HPV-related Multiphenotypic Sinonasal Carcinoma: An Expanded Series of 49 Cases of the Tumor Formerly Known as HPV-related Carcinoma With Adenoid Cystic Carcinoma-like Features.". Am J Surg Pathol 41 (12): 1690-1701. doi:10.1097/PAS.0000000000000944. PMID 28877065.
- ↑ Andreasen, S.; Bishop, JA.; Hansen, TV.; Westra, WH.; Bilde, A.; von Buchwald, C.; Kiss, K. (May 2017). "Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: clinical and morphological characterization of six new cases.". Histopathology 70 (6): 880-888. doi:10.1111/his.13162. PMID 28035703.
- ↑ Bishop, JA.; Ogawa, T.; Stelow, EB.; Moskaluk, CA.; Koch, WM.; Pai, SI.; Westra, WH. (Jun 2013). "Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract.". Am J Surg Pathol 37 (6): 836-44. doi:10.1097/PAS.0b013e31827b1cd6. PMID 23598962.
- ↑ Oramas DM, Bell D, Middleton LP (November 2020). "Sinonasal analogue HPV related breast multiphenotypic carcinoma, a report of a case with the first description in the breast". Diagn Pathol 15 (1): 137. doi:10.1186/s13000-020-01050-7. PMC 7678216. PMID 33218360. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678216/.
- ↑ Hang, JF.; Hsieh, MS.; Li, WY.; Chen, JY.; Lin, SY.; Liu, SH.; Pan, CC.; Kuo, YJ. (Jun 2017). "Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features: A Series of 5 Cases Expanding the Pathologic Spectrum.". Histopathology. doi:10.1111/his.13301. PMID 28664668.