Difference between revisions of "Eosinophilic colitis"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      =  
| Image      = Eosinophilic_colitis_-_alt_--_high_mag.jpg
| Width      =
| Width      =
| Caption    =  
| Caption    = Eosinophilic colitis. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      = abundant eosinophils - no agreed upon number - "most use 20/HPF", there is variation along the large bowel - normal in rectum <10/HPF, normal in cecum <30/HPF
| Micro      = abundant eosinophils - no agreed upon number - "most use 20/HPF", there is variation along the large bowel - normal in rectum <10/HPF, normal in cecum <30/HPF
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*[[Drug reaction]]s.
*[[Drug reaction]]s.


Image:
===Images===
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702104/figure/F1/ EC (nih.gov)].<ref name=pmid19554649>{{Cite journal  | last1 = Okpara | first1 = N. | last2 = Aswad | first2 = B. | last3 = Baffy | first3 = G. | title = Eosinophilic colitis. | journal = World J Gastroenterol | volume = 15 | issue = 24 | pages = 2975-9 | month = Jun | year = 2009 | doi =  | PMID = 19554649 | PMC = 2702104 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702104/figure/F1/ EC (nih.gov)].<ref name=pmid19554649>{{Cite journal  | last1 = Okpara | first1 = N. | last2 = Aswad | first2 = B. | last3 = Baffy | first3 = G. | title = Eosinophilic colitis. | journal = World J Gastroenterol | volume = 15 | issue = 24 | pages = 2975-9 | month = Jun | year = 2009 | doi =  | PMID = 19554649 | PMC = 2702104 }}</ref>
<gallery>
Image: Eosinophilic colitis -- intermed mag.jpg | EC - intermed. mag. (WC)
Image: Eosinophilic colitis -- high mag.jpg | EC - high mag. (WC)
Image: Eosinophilic colitis - alt -- high mag.jpg | EC - high mag. (WC)
Image: Eosinophilic colitis -- very high mag.jpg | EC - very high mag. (WC)
Image: Eosinophilic colitis - alt -- very high mag.jpg | EC - very high mag. (WC)
</gallery>


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Revision as of 23:03, 17 January 2014

Eosinophilic colitis
Diagnosis in short

Eosinophilic colitis. H&E stain.
LM abundant eosinophils - no agreed upon number - "most use 20/HPF", there is variation along the large bowel - normal in rectum <10/HPF, normal in cecum <30/HPF
Site colon
Blood work +/-eosinophilia
Treatment dependent on underlying cause

Eosinophilic colitis, abbreviated EC, is an inflammatory process involving the colon (colitis) characterized by abundant eosinophils.

General

Clinical features:[1]

  • Abdominal pain
  • Diarrhea +/-blood.
  • +/-Weight loss.

Gross

Features - endoscopic:[1]

  • Edema.
  • Granular appearance.

Microscopic

Features:[1]

  • Abundant eosinophils - no agreed upon number.
    • "Most use 20/HPF" [2] - a definition that suffers from HPFitis.
      • There is variation along the large bowel - normal in rectum <10/HPF, normal in cecum <30/HPF.[2]

DDx:[1]

Images

www:

  • EC - intermed. mag. (WC)

  • EC - high mag. (WC)

  • EC - high mag. (WC)

  • EC - very high mag. (WC)

  • EC - very high mag. (WC)

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DESCENDING COLON, BIOPSY:
- COLONIC MUCOSA WITH MILD EOSINOPHILIA, SEE COMMENT.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
Focally, there are up to 40 eosinophils / 0.2376 mm*mm (approx. field area at 400X). This
is a non-specific finding. No eosinophilic crypt abscesses are seen. No (neutrophilic)
cryptitis is present. Clinical correlation is suggested.

DESCENDING COLON, BIOPSY:
- COLONIC MUCOSA WITH MILD EOSINOPHILIA, SEE COMMENT.
- NEGATIVE FOR ACTIVE COLITIS.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
There are up to 40 eosinophils / 0.2376 mm*mm (field area at 400X). This is a 
non-specific finding.  The differential diagnosis includes inflammatory bowel 
disease, infection (especially helminths), a drug reaction, and autoimmune 
disorders (e.g. Churg-Strauss syndrome, celiac disease, scleroderma). Clinical 
correlation is required.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Alfadda, AA.; Storr, MA.; Shaffer, EA. (2011). "Eosinophilic colitis: an update on pathophysiology and treatment.". Br Med Bull 100: 59-72. doi:10.1093/bmb/ldr045. PMC 3165205. PMID 22012125. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165205/.
  2. ↑ 2.0 2.1 2.2 Okpara, N.; Aswad, B.; Baffy, G. (Jun 2009). "Eosinophilic colitis.". World J Gastroenterol 15 (24): 2975-9. PMC 2702104. PMID 19554649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702104/. Cite error: Invalid <ref> tag; name "pmid19554649" defined multiple times with different content
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