Blood work

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This article takes a superficial look at blood work. Blood work is often essential definitively diagnostic.

In many medical diseases, it is an essential component and should be considered by the pathologist; thus, it is important to be familiar with common blood tests.

Pathology & blood work

Pathology Key blood work
Primary biliary cirrhosis AMA +ve[1]
Autoimmune hepatitis ANA +ve, LKM-1 +ve, SMA +ve, IgG high[2]
Celiac disease Anti-tissue transglutaminase +ve, anti-endomysial +ve, IgA deficiency
Systemic lupus erythematosus ANA +ve, anti-dsDNA +ve, Anti-Sm +ve
Sjögren syndrome Anti-SS-A/Ro +ve, Anti-SS-B/La +ve, ANA +ve[3]
Scleroderma Anti-topoisomerase (ATA), Anti-centromere (ACA), anti-Scl-70 (type of ATA)
Mixed connective tissue disease anti-U1-RNP (ribonucleoprotein) +ve,[4] ANA +ve (speckled)

See also


  1. Nguyen, DL.; Juran, BD.; Lazaridis, KN. (Oct 2010). "Primary biliary cirrhosis.". Best Pract Res Clin Gastroenterol 24 (5): 647-54. doi:10.1016/j.bpg.2010.07.006. PMID 20955967.
  2. Scoring systems for the diagnosis of autoimmune hepatitis: past, present, and future. Wiegard C, Schramm C, Lohse AW. Semin Liver Dis. 2009 Aug;29(3):254-61. Epub 2009 Aug 12. PMID 19675998
  3. "Information from your family doctor. Sjögren syndrome.". Am Fam Physician 79 (6): 472. Mar 2009. PMID 19323360.
  4. Sato, T.; Fujii, T.; Yokoyama, T.; Fujita, Y.; Imura, Y.; Yukawa, N.; Kawabata, D.; Nojima, T. et al. (Dec 2010). "Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.". Arthritis Rheum 62 (12): 3730-40. doi:10.1002/art.27700. PMID 20722023.