Difference between revisions of "Dermatologic neoplasms"

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(→‎Microcystic adnexal carcinoma: +trichilemmal carcinoma)
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====Subtypes/unique features====
====Subtypes/unique features====
*Many patterns exist.
*Many patterns exist.
*The prognosis is similar for all of the BCC subtypes -- except for ''sclerosing'' variant and ''infiltrating nested'' variant.<ref>DG. 14 September 2011.</ref>
*Recurrence higher in morpheaform (sclerosing), infiltrative, micronodular, and superficial patterns.<ref>Basal cell carcinoma. eMedicine. ''Prognosis'' section. URL: [http://emedicine.medscape.com/article/276624-overview http://emedicine.medscape.com/article/276624-overview]. Accessed on: 17 September 2011.</ref>
*DG says the prognosis is similar for all BCC subtypes, except for ''sclerosing'' pattern and ''infiltrative'' pattern.<ref>DG. 14 September 2011.</ref>


The subtypes:<ref name=Ref_Derm392-5>{{Ref Derm|392-5}}</ref>
The subtypes:<ref name=Ref_Derm392-5>{{Ref Derm|392-5}}</ref>

Revision as of 02:00, 18 September 2011

This article deals with dermatologic neoplasms. It includes dermatologic cancer, which can be deadly. Collectively, dermatologic cancers are the most common form of cancer.

An introduction to dermatopathy is found in the dermatopathology article. Non-malignant disease is covered in the non-malignant skin disease article.

The Big Three malignant

Basal cell carcinoma

  • Abbreviated BCC.

General

  • Very common.
  • Sun exposed skin.
  • Hair bearing area; tumour derived from hair follicle - a more appropriate name might be trichoblastic carcinoma.[1]
  • Very rarely metastasizes:
    • Dermatopathologists might see a couple in their career.
    • There are only ~ 300 literature reports of metastatic BCC.[2]

Clinical

  • Telangiectasias.
  • Raised pearly nodule.

As part of a syndrome

Microscopic

Features:[4][5]

  1. Basaloid cells - similar in appearance to basal cells:
    • Moderate blue/grey cytoplasm.
    • Dark ovoid/ellipsoid nucleus with uniform chromatin.
  2. Palisading of cells at the edge of the cell nests.
  3. Artefactual separation of cells (forming the nests) from the underlying stroma - key feature.
  4. Surrounded by blue (myxoid) stroma - key feature.

May be present:[5]

  • Dystrophic calcification.
  • Amyloid.
  • Inflammation.

Notes:

  • Palisading = the long axes of the cells are alined and the axes are perpendicular to the interface between the (basaloid cell) nests and stroma.
  • Key elements in a list: Artefactual clefting (of nests), Basaloid cells, Peripheral palisading, Myxoid stroma.
    • Memory device PAM: palisading, artefactual clefts, myxoid stroma.

DDx:

Images:

Subtypes/unique features

  • Many patterns exist.
  • Recurrence higher in morpheaform (sclerosing), infiltrative, micronodular, and superficial patterns.[8]
  • DG says the prognosis is similar for all BCC subtypes, except for sclerosing pattern and infiltrative pattern.[9]

The subtypes:[10]

Pattern Key histologic feature Other histologic features Other
Superficial pattern connected to epidermis
Nodular pattern nodules partial detachment from epidermis subgroup micronodular = nests equal size ~ 0.2 mm dia., >=25% of lesion
Morpheaform (sclerosing) pattern stroma sclerosis often seen with infiltrative pattern
Infiltrative pattern small irregular cell aggregates often also sclerosing or morpheaform
Fibroepitheliomatous pattern cords and columns of basaloid cells fibrous stroma name of pattern comes from fibroepithelioma of Pinkus
Infundibulocystic pattern small keratocysts (keratin cysts) usu. small, often in cords usu. indolent
Adenoidal pattern cribriform / pseudoglandular arch. myxoid stroma, peripheral palisading DDx: adenoid cystic carcinoma

Unique features/differentiation:[10]

Differentiation / unique cell Key histologic feature Other histologic features Other
Pigmented cells any pattern can have pigmentation pigment may be in malignant cell DDx: collision lesion with melanocytic lesion
Squamous differentiation (metatypical BCC) pink cytoplasm, keratinization assoc. with ulceration/tumour recurrence
Eccrine differentiation focal duct formation very rare, DDx: BCC engulfing sweat ducts
Clear cells (Clear cell BCC) clear cytoplasm due to glycogen

IHC

  • CK5/6 +ve.
    • Useful to assess margins... if very close.

Squamous cell carcinoma

General

Precursor:[11]

  • Actinic keratosis (solar keratosis).
    • Clinical: yellow-brown scaly, patches, sandpaper sensation.

Risk factors:[11]

  • Sun exposure.
  • Immune suppression (e.g. organ transplant recipients).

Notes:

  • Keratoacanthoma.
    • Some don't believe this entity exists.
      • These people sign this entity as low grade squamous cell carcinoma, keratoacanthoma type.[12]

Microscopic

Bowen disease

Bowen disease is squamous cell carcinoma in situ of the skin.

  • Its histomorphologic appearance may be similar to Paget disease, Toker cell hyperplasia and melanoma. **IHC is used to separate the entities definitively.

Histologic DDx of Bowen disease:

Images:

IHC

Bowen's disease panel:

Melanoma

General

  • Known as the great mimicker in pathology; it may look like many things.

Microscopic

Features:

  • Classic appearance of melanoma:
    • Loosely cohesive; mix of small nests of cells, single cells.
    • Mixed of spindle and ovoid cell morphology.
    • +/-Occasional large binucleated cells.
    • Cytoplasm: brown pigment (melanin).
    • Prominent (large) red nucleoli (like in serous carcinoma of the ovary).
    • Marked nuclear pleomorphism - variation in cell size, shape & staining (like in serous carcinoma of the ovary).
    • Nuclear pseudoinclusions (like in papillary thyroid carcinoma).

Less common malignant

Dermatofibrosarcoma protuberans

  • Abbreviated DFSP.

General

  • Dermal location.
  • Destroys adnexal structures.

Treatment:[16]

  • Wide excision.
  • May include imatinib (Gleevec).

Microscopic

Features:[16]

  • Dermal spindle cell lesion with storiform pattern.
    • Spokes of the wheel-pattern.
  • Contains adipose tissue within the tumour -- key feature.
    • Described as "honeycomb pattern" and "Swiss cheese pattern".

Notes:

  • Adnexal structure within tumour are preserved -- this is unusual for a malignant tumour -- important.


Main DDx:

  • Dermatofibroma - has entrapment of collagen bundles at the edge of the lesion.

DDx of storiform pattern:

Images:

IHC

Panel:[17]

  • CD34 +ve.
    • Usually negative in dermatofibroma.[18][19]
  • Factor XIIIa -ve.
    • Usually positive in dermatofibroma.[18][19]
  • S100 -ve (screen for melanoma).
  • Caldesmin -ve (screen for muscle differentiation).
  • Beta-catenin. (???)
  • MIB-1 (proliferation marker).
    • Should not be confused with MIB1 a gene that regulates apoptosis.

Molecular

A characteristic translocation is seen:[20] t(17;22)(q22;q15) COLA1/PDGFB.

Cutaneous B-cell lymphoma

  • Abbreviated CBCL.

General

  • CBCL is less common than cutaneous T-cell lymphoma (CTCL).[21]

Microscopic

Features:

  • Dermal lymphoid infiltrate.
  • "Grenz zone" - space between the epidermis and the dermal infiltrate - key feature.

IHC

  • B cell and T cell markers.

Cutaneous T-cell lymphoma

  • Abbreviated CTCL.

General

  • Mycosis fungoides - is a subtype (???).
  • CTCL is more common than cutaneous B-cell lymphoma (CBCL).[22][23]

Microscopic

  • Atypical lymphocytes:
    • Have folded "cerebriform" nuclei; Sezary-Lutzner cells.[24]
  • Grouping:
    • Nests in the epidermis - known as "Pautrier microabscesses".
    • Single lymphocytes in epidermis; "lymphocyte exocytosis".[25]
    • Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".[24]

DDx:

Images:

IHC

Key stain:

Other stains:

  • CD3 +ve.
  • CD8 -ve.
  • CD20 -ve (to r/o significant B cell population).
  • CD30 -ve.
  • CD5 +ve.
  • CD7 -ve (often lost first in T cell lymphomas).
  • Ki-67 high.
  • CD56 -ve.

Lymphomatoid papulosis.

General

  • Rare.
  • Benign behaviour.

Microscopic

Features:

  • Dermal lymphocytosis.
    • No epidermal lymphocytes.
  • Focal nuclear atypia.

DDx:

Merkel cell carcinoma

  • Abbreviated MCC.

General

  • Aggressive.
  • Rare.
  • Increased risk in the immunodeficient.
  • Most caused by Merkel cell polyomavirus.[27]

General

Features:[28]

  • Rare.
  • Aggressive course/poor prognosis.
  • Neuroendocrine-like.[29]

Etiology:

  • Polyomavirus (?).[28]
  • Immunocompromised/immunosuppressed (e.g. organ transplant recipients).

Microscopic

Features:[30]

  • Neuroendocrine nuclear features - round nucleus, small nucleoli/no nucleolus, stippled chromatin - key feature.
  • Typically medium size cells ~3x resting lymphocyte.
    • May be small or large.
  • Architecture: nests, sheets or trabeculae.
  • Scant cytoplasm.
  • Abundant mitoses.
  • +/-Nuclear moulding.

DDx:

Images:

IHC

Features:

  • CK7 -ve.
  • CK20 +ve (perinuclear ???).
  • CAM5.2 +ve (dot-like pattern).

Others:

  • TTF-1 -ve.

Eccrine carcinoma

General

  • Arises from the proximal sweat duct.

Microscopic

Features:

  • Pleomorphic nuclei with nucleoli.
  • Duct-like structures - key feature.
  • Extends from dermis into epidermis (follows path of a benign sweat duct).

Notes:

Images:

Kaposi sarcoma

See Kaposi sarcoma.

Sebaceous carcinoma

General

Notes:

Microscopic

Features:

  • Nuclear atypia.
  • Sebaceous differentiation:
    • Abundant pale fluffy cytoplasm.

Image:

Microcystic adnexal carcinoma

  • AKA syringomatous carcinoma, AKA sclerosing sweat duct carcinoma.[32]

General

  • Low-grade tumour.
  • Adults.

Microscopic

Features:[33]

  • Small basaloid cells - often forming small cystic spaces - key feature.
  • Fibrotic stroma.

DDx:

Image:

Trichilemmal carcinoma

General

  • Super rare.
  • Not well-described.

Microscopic

Features:[34]

  • Clear (glycogen-rich) cytoplasm in center of lesion.
  • Peripheral palisading at edge of lesion - root sheath differentiation (hair follicle).
  • Contiguous with hair follicle or assoc. with trichilemmoma.

DDx:

Intermediate

Atypical fibroxanthoma

  • Abbreviated AFX.

General

Clinical:

  • Rapid growth.
  • Elderly.
  • Good prognosis.[38]

Microscopic

Features:[39]

  • Dermal lesion - key point.
  • Marked nuclear atypia.
  • Mitoses.
  • Mulitnucleated cells.
  • Foamy cytoplasm - key feature.

DDx:

Notes:

  • No Grenz zone. (???)

Image:

IHC

Features:[39]

  • S100 -ve (done to r/o melanoma).
  • 34betaE12 -ve, p63 -ve (done to exclude SCC).
  • Desmin -ve (done to r/o leiomyosarcoma).

Benign

Sebaceous adenoma

General

Microscopic

Features:

  • Abnormal sebaceous glands (pale fluffy cytoplasm):
    • Increased basal epithelium.
    • Multiple dilated glands - opening to the surface.

Image:

Trichilemmoma

  • May be spelled tricholemmoma.

General

  • Benign neoplasm with features of the pilosebaceous follicular epithelium.[41]
  • Associated with nevus sebaceous.[42]
  • Muliple trichilemmomas associated with Cowden syndrome.[43]

Microscopic

Features:[43]

  • Superficial dermal lesion contiguous with the epidermis:
    • Core of lesion:
      • Cuboidal cells with round nuclei, eosinophilic-clear cytoplasm.
    • Periphery of lesion:
      • Surrounded by hyaline band.
      • Peripheral palisading.

Images:

DDx:

Eccrine poroma

  • AKA nodular hidradenoma. (???)

General

  • Benign tumour arising from the distal sweat duct.
  • Erythematous - gross.

Microscopic

Features:[46]

  • Broad sheets of basaloid cells containing ductal structures - key feature.
  • Biphasic stroma:
    1. Edematous stroma.
    2. Sclerotic stroma.
  • Moderate nuclear pleomorphism.
  • +/-Occasional mitoses.

Notes:

  • Area above gland appears crusted.

Images:

Trichoblastoma

  • AKA trichoepithelioma.
    • Trichoepithelioma is considered a superficial version of trichoblastoma; WHO lumps the two entities together.[47]

General

  • Benign.
  • May be familial:
    • Multiple familial trichoepithelioma.[48]
    • Brooke-Spiegler syndrome.

Microscopic

Features:[49]

  • Well-circumscribed cell nest in the superficial dermis.
  • Surrounding by a fibrous stroma.
  • Basaloid cells with peripheral pallisading.
  • +/-Surround keratin-filled cysts.
  • Fibroblasts-like cell aggregate, similar to a follicular papillae (papillary-mesenchymal body).

Notes:

Variants:

  • Desmoplastic trichoblastoma.

DDx:

Images:

See also

References

  1. Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 389. ISBN 978-0443066542.
  2. Ting, PT.; Kasper, R.; Arlette, JP. (Jan 2005). "Metastatic basal cell carcinoma: report of two cases and literature review.". J Cutan Med Surg 9 (1): 10-5. doi:10.1007/s10227-005-0027-1. PMID 16208438.
  3. URL: http://emedicine.medscape.com/article/1101146-diagnosis. Accessed on: 6 May 2010.
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