Secretory carcinoma of the breast
Secretory carcinoma of the breast is an uncommon form of invasive breast cancer that has an appearance similar to breast with lactational changes.
| Secretory carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
| LM DDx | lactational change |
| IHC | ER -ve, PR -ve, HER2 -ve, alpha-lactalbumin +ve, S-100 +ve, polyclonal CEA +ve |
| Grossing notes | breast grossing |
| Staging | breast cancer staging |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | rare |
| Prognosis | favourable |
It is also known as secretory breast carcinoma (abbreviated SBC) and breast secretory carcinoma.
General
- Favourable prognosis.[1]
- Children and adults.
Microscopic
Features:[2]
- Abundant cytoplasm with fine vacuolation - clear/pale or amphophilic.
- Mitoses - uncommon.
- Nucleoli - rare.
- Architecture: solid, papillary, cribriform or microcystic.
DDx:
- Lactational change[3] - glandular architecture.
Images
IHC
Triple negative (ER -ve, PR -ve, HER2 -ve).[1]
Others:
- Alpha-lactalbumin +ve.
- S-100 protein +ve.
- Polyclonal CEA +ve.
Molecular pathology
Characteristic translocation:[1]
- t(12;15).
- ETV6-NTRK3.
Note:
- This translocation is also seen in mammary analogue secretory carcinoma,[4] congenital-infantile fibrosarcoma and mesoblastic nephroma.
See also
References
- ↑ 1.0 1.1 1.2 Vasudev, P.; Onuma, K. (Dec 2011). "Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression.". Arch Pathol Lab Med 135 (12): 1606-10. doi:10.5858/arpa.2010-0351-RS. PMID 22129193.
- ↑ Laé, M.; Fréneaux, P.; Sastre-Garau, X.; Chouchane, O.; Sigal-Zafrani, B.; Vincent-Salomon, A. (Feb 2009). "Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum.". Mod Pathol 22 (2): 291-8. doi:10.1038/modpathol.2008.184. PMID 19011601.
- ↑ Vesoulis, Z.; Kashkari, S.. "Fine needle aspiration of secretory breast carcinoma resembling lactational changes. A case report.". Acta Cytol 42 (4): 1032-6. PMID 9684599.
- ↑ Skálová, A.; Vanecek, T.; Sima, R.; Laco, J.; Weinreb, I.; Perez-Ordonez, B.; Starek, I.; Geierova, M. et al. (May 2010). "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.". Am J Surg Pathol 34 (5): 599-608. doi:10.1097/PAS.0b013e3181d9efcc. PMID 20410810.