LP:Sandbox

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Atypical granulocytic lineage cells in a patient with myelodysplasia.

Atypical ductal hyperplasia. Very low magnification. H&E stain. (WC/Nephron)

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Section

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Tubular adenomas are a precursor CRC

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DOI

doi:10.1038/ng.2868

doi:10.1038/ng.2868

Test 1

Translocations Chr 1-10 Test Result t(1;13) PAX7-FKHR {{{blank}}} t(2,13) PAX3-FKHR {{{blank}}} t(8;14) MYC-IGH {{{blank}}} t(9;22) BCR-ABL {{{blank}}} t(9;22) CHN-EWS {{{blank}}}	Translocations Chr 11-13 Test Result t(11;14) CCND1-IGH {{{blank}}} t(11;22) EWS-WT1 {{{blank}}} t(11;22) FLI1-EWS {{{blank}}} t(12;15) ETV6-NTRK3 {{{blank}}} t(12;16) FUS-ATF1 {{{blank}}} t(12;16) CHOP-TLS {{{blank}}} t(12;22) EWS-ATF1 {{{blank}}}	Translocations Chr 14-22 Test Result t(14,18) IGH-BCL2 {{{blank}}} t(15;17) PML-RARA {{{blank}}} t(16;21) FUS-ERG {{{blank}}} t(17;22) COLA1-PDGFB {{{blank}}} t(21;22) EWS-ERG {{{blank}}}	Translocations Chr X & Y Test Result t(X;1) PRCC-TFE3 {{{blank}}} t(X;17) TFE3-ASPL {{{blank}}} t(X;18) SYT-SSX {{{blank}}}

Test 2

Translocations Chr 1-10 Test Result t(1;13) PAX7-FKHR {{{blank}}} t(2,13) PAX3-FKHR {{{blank}}} t(8;14) MYC-IGH {{{blank}}} t(9;22) BCR-ABL {{{blank}}} t(9;22) CHN-EWS {{{blank}}}	Translocations Chr X & Y Test Result t(X;1) PRCC-TFE3 {{{blank}}} t(X;17) TFE3-ASPL {{{blank}}} t(X;18) SYT-SSX {{{blank}}}

Test 3

Molecular tests Test Result LOH 1p/19q PCR {{{blank}}} IDH1/2 PCR {{{blank}}} BRAF sequencing {{{blank}}} KIT sequencing {{{blank}}}	More molecular tests Test Result H3F3A sequencing {{{blank}}} EGRF sequencing {{{blank}}} ALK sequencing {{{blank}}}	Heme molecular tests Test Result BCL2 PCR {{{blank}}} T cell clonality Southern / PCR {{{blank}}} B cell clonality Southern / PCR {{{blank}}}	More heme molecular tests Test Result JAK2 V617F ARMS {{{blank}}} EBV PCR {{{blank}}} HHV-8 PCR {{{blank}}}

Test 4

Alpha-1 AT to Cathepsin K Test Result alpha-1 AT ACTH AE1/AE1 alpha-fetoprotein Alk-I AMACR AR ATRX Beta2-microglobulin B72.3 Beta-catenin BCL2 BCL6 BCLxL C3 comp CA9 Calcitonin Calponin Calretinin CAM5.2 Cathepsin K	CD10 to Chromogranin Test Result CD10 CD117 CD138 CD15 CD1a CD20 CD21 CD23 CD3 CD30 CD31 CD34 CD35 CD4 CD43 CD45 (LCA) CD5 CD56 CD57 CD68 CD7 CD79a CD8 CD99 CDX2 CEA-m Chromogranin	CK17 to Glypican 3 Test Result CK17 CK19 CK20 CK34betaE12 CK5/6 CK7 CMV c-MYC Cyclin D1 D2-40 Desmin DOG1 EBV EMA ER and PR Factor VIII Factor XIIIa Fascin FH FSH Gastrin GATA3 GCDFP-15 (BRST2) GFAP GH Glucagon Glypican-3	HBME-1 to IgM Test Result HBME-1 HBV core HBV surface H-caldesmon HCG Helicobacter Hepatocyte HER2/neu HHV-8 HMB-45 HNF1beta HPV HSV-I HSV-II IDH-1 Inhibin INI1 (BAF47) Insulin Kappa Ki-67 Lambda Leu 7 IgA IgG IgM	LH to PDGFR Test Result LH LIN28 Lysozyme mammoglobin MAP2 MCV Melanin A MHC class I MITF MUM1 Myeloperoxidase MYO D1 Myoglobin Napsin POSITIVE NF NKX3.1 NSE OCT3/4 p16 P501S p53 p57 p63 Pankeratin PAX2 PAX5 PAX8 PCNA PDGFR	PLAP to WT1 Test Result PLAP PNL-2C Prolactin PSA PSAP RCC S-100 SALL4 Smooth muscle actin Somatostatin STAT6 Synaptophysin TdT TFE3 TFEB Thyroglobulin Toxoplasma TSH TTF-1 Ubiquitin UCHL1 (PGP9.5) Ulex Europaeus Vimentin VIP VZV WT-1

See also

• Sandbox.