Provided clinical history
62 year old man, bladder tumour
SitePrimary image
Low magnification. H&E stain.
Intermediate magnification
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Intermediate magnification. H&E stain.
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Very high magnification
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Very high magnification. H&E stain.
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Differential diagnosisAdditional tests
More history
More history
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No history of bladder cancer. PSA normal.
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Ask a colleague
Ask a colleague
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Looks glandular.
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Stains
| Alcian blue/PAS to Bilirubin |
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| Test | Result |
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| Alcian blue/PAS | Dr Torres would ask why! |
| Alican blue pH 1.0 | Dr Torres would ask why! |
| Alcian blue pH 2.5 | Dr Torres would ask why! |
| Auramine | Dr Torres would ask why! |
| Bielchowsky | Dr Torres would ask why! |
| Bilirubin | Dr Torres would ask why! |
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| Colloidal iron to Fontana-Masson |
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| Test | Result |
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| Colloidal iron | Dr Torres would ask why! |
| Congo red | Dr Torres would ask why! |
| Cresyl violet | Dr Torres would ask why! |
| Dieterle | Dr Torres would ask why! |
| Diff Quik | Dr Torres would ask why! |
| Fontana-Masson | Dr Torres would ask why! |
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| Gallyas to Gremelius |
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| Test | Result |
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| Gallyas | Dr Torres would ask why! |
| Giemsa | Dr Torres would ask why! |
| GMS | Dr Torres would ask why! |
| Gomori's trichrome | Dr Torres would ask why! |
| Gram | Dr Torres would ask why! |
| Gremelius | Dr Torres would ask why! |
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| JMS to Mucicarmine |
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| Test | Result |
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| JMS | Dr Torres would ask why! |
| Jones | Dr Torres would ask why! |
| Kinyoun | Dr Torres would ask why! |
| Luxol fast blue | Dr Torres would ask why! |
| Masson trichrome | Dr Torres would ask why! |
| M-MAS | Dr Torres would ask why! |
| Movat | Dr Torres would ask why! |
| Mucicarmine | Dr Torres would ask why! |
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| Oil red O to Prussian blue |
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| Test | Result |
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| Oil red O | Dr Torres would ask why! |
| Orecein | Dr Torres would ask why! |
| PAS | Dr Torres would ask why! |
| PASD | Dr Torres would ask why! |
| PASF | Dr Torres would ask why! |
| PTAH | Dr Torres would ask why! |
| Prussian blue | Dr Torres would ask why! |
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| Reticulin to Ziehl-Neelsen |
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| Test | Result |
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| Reticulin | Dr Torres would ask why! |
| Sudan black B | Dr Torres would ask why! |
| Toluidine blue | Dr Torres would ask why! |
| Verhoeff | Dr Torres would ask why! |
| Von Kossa | Dr Torres would ask why! |
| Warthin-Starry | Dr Torres would ask why! |
| Ziehl-Neeslen | Dr Torres would ask why! |
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IHC
| Alpha-1 AT to Cathepsin K |
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| Test | Result |
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| alpha-1 AT | |
| ACTH | |
| AE1/AE1 | |
| alpha-fetoprotein | |
| Alk-I | |
| AMACR | -ve |
| AR | |
| ATRX | |
| Beta2-microglobulin | |
| B72.3 | |
| Beta-catenin | |
| BCL2 | |
| BCL6 | |
| BCLxL | |
| C3 comp | |
| CA9 | |
| Calcitonin | |
| Calponin | |
| Calretinin | |
| CAM5.2 | |
| Cathepsin K | |
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| CD10 to Chromogranin |
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| Test | Result |
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| CD10 | |
| CD117 | |
| CD138 | |
| CD15 | |
| CD1a | |
| CD20 | |
| CD21 | |
| CD23 | |
| CD3 | |
| CD30 | |
| CD31 | |
| CD34 | |
| CD35 | |
| CD4 | |
| CD43 | |
| CD45 (LCA) | |
| CD5 | |
| CD56 | |
| CD57 | |
| CD68 | |
| CD7 | +ve |
| CD79a | |
| CD8 | |
| CD99 | |
| CDX2 | |
| CEA-m | -ve |
| Chromogranin | |
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| CK17 to Glypican 3 |
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| Test | Result |
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| CK17 | |
| CK19 | |
| CK20 | |
| CK34betaE12 | |
| CK5/6 | |
| CK7 | |
| CMV | |
| c-MYC | |
| Cyclin D1 | |
| D2-40 | |
| Desmin | |
| DOG1 | |
| EBV | |
| EMA | |
| ER and PR | |
| Factor VIII | |
| Factor XIIIa | |
| Fascin | |
| FH | |
| FSH | |
| Gastrin | |
| GATA3 | |
| GCDFP-15 (BRST2) | |
| GFAP | |
| GH | |
| Glucagon | |
| Glypican-3 | |
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| HBME-1 to IgM |
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| Test | Result |
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| HBME-1 | |
| HBV core | |
| HBV surface | |
| H-caldesmon | |
| HCG | |
| Helicobacter | |
| Hepatocyte | |
| HER2/neu | |
| HHV-8 | |
| HMB-45 | |
| HNF1beta | |
| HPV | |
| HSV-I | |
| HSV-II | |
| IDH-1 | |
| Inhibin | |
| INI1 (BAF47) | |
| Insulin | |
| Kappa | |
| Ki-67 | <5% |
| Lambda | |
| Leu 7 | |
| IgA | |
| IgG | |
| IgM | |
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| LH to PDGFR |
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| Test | Result |
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| LH | |
| LIN28 | |
| Lysozyme | |
| mammoglobin | |
| MAP2 | |
| MCV | |
| Melanin A | |
| MHC class I | |
| MITF | |
| MUM1 | |
| Myeloperoxidase | |
| MYO D1 | |
| Myoglobin | |
| Napsin | |
| NF | |
| NKX3.1 | |
| NSE | |
| OCT3/4 | |
| p16 | |
| P501S | |
| p53 | -ve |
| p57 | |
| p63 | |
| Pankeratin | |
| PAX2 | +ve |
| PAX5 | |
| PAX8 | +ve |
| PCNA | |
| PDGFR | |
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| PLAP to WT1 |
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| Test | Result |
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| PLAP | |
| PNL-2C | |
| Prolactin | |
| PSA | -ve |
| PSAP | -ve |
| RCC | |
| S-100 | |
| SALL4 | |
| Smooth muscle actin | |
| Somatostatin | |
| STAT6 | |
| Synaptophysin | |
| TdT | |
| TFE3 | |
| TFEB | |
| Thyroglobulin | |
| Toxoplasma | |
| TSH | |
| TTF-1 | |
| Ubiquitin | |
| UCHL1 (PGP9.5) | |
| Ulex Europaeus | |
| Vimentin | |
| VIP | |
| VZV | |
| WT-1 | |
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Chromosomal translocations
| Translocations Chr 1-10 |
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| Test | Result |
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| t(1;13) PAX7-FKHR | Dr Torres would ask why! |
| t(2,13) PAX3-FKHR | Dr Torres would ask why! |
| t(8;14) MYC-IGH | Dr Torres would ask why! |
| t(9;22) BCR-ABL | Dr Torres would ask why! |
| t(9;22) CHN-EWS | Dr Torres would ask why! |
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| Translocations Chr 11-13 |
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| Test | Result |
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| t(11;14) CCND1-IGH | Dr Torres would ask why! |
| t(11;22) EWS-WT1 | Dr Torres would ask why! |
| t(11;22) FLI1-EWS | Dr Torres would ask why! |
| t(12;15) ETV6-NTRK3 | Dr Torres would ask why! |
| t(12;16) FUS-ATF1 | Dr Torres would ask why! |
| t(12;16) CHOP-TLS | Dr Torres would ask why! |
| t(12;22) EWS-ATF1 | Dr Torres would ask why! |
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| Translocations Chr 14-22 |
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| Test | Result |
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| t(14,18) IGH-BCL2 | Dr Torres would ask why! |
| t(15;17) PML-RARA | Dr Torres would ask why! |
| t(16;21) FUS-ERG | Dr Torres would ask why! |
| t(17;22) COLA1-PDGFB | Dr Torres would ask why! |
| t(21;22) EWS-ERG | Dr Torres would ask why! |
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| Translocations Chr X & Y |
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| Test | Result |
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| t(X;1) PRCC-TFE3 | Dr Torres would ask why! |
| t(X;17) TFE3-ASPL | Dr Torres would ask why! |
| t(X;18) SYT-SSX | Dr Torres would ask why! |
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DiagnosisOther cases
