Inflammatory pseudopolyp

Inflammatory pseudopolyp is a benign polypoid lesion usually seen in the context of inflammatory bowel disease.

Inflammatory pseudopolyp
Diagnosis in short
Inflammatory polyp. H&E stain.
LM	polypoid shape, inflammatory cells - esp. neutrophils
LM DDx	juvenile polyp, mucosal prolapse, adenomatous polyps
Site	colon, rectum, others
Clinical history	+/-inflammatory bowel disease
Prevalence	not common
Prognosis	benign
Clin. DDx	other types of polyps

Inflammatory pseudopolyp
External resources
EHVSC	9992

It is also referred to as inflammatory polyp.

General

• Not a true polyp.
• The label inflammatory pseudopolyp = inflammatory bowel disease (IBD).
  • If there is no history of IBD... reconsider the diagnosis.

Microscopic

Features:

• Polypoid shape.
• Inflammation - esp. neutrophils - key feature.

Negatives:

• No nuclear atypia.
  • May have focal nuclear hyperchromasia and nuclear enlargement.
• No dilated glands.

DDx:

• Juvenile polyp.
• Mucosal prolapse.
  • Solitary rectal ulcer.

Images:

• Pseudopolyp (humpath.com).
• Pseudopolyp (ucsf.edu).

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SIGMOID COLON POLYP, PERI-DIVERTICULAR, BIOPSY:
- INFLAMMATORY PSEUDOPOLYP.

POLYP, DESCENDING COLON, BIOPSY:
- INFLAMED POLYPOID FRAGMENT OF COLORECTAL-TYPE MUCOSA.
-- NEGATIVE FOR DYSPLASIA.

Micro

The sections show a fragment of colorectal mucosa with focal ulceration, acute inflammation and a well-vascularized stroma with plump stromal cells. Occasional stromal cells have nuclear hyperchromasia.

See also

• Gastrointestinal tract polyps.
• Mucosal prolapse syndrome.
• Colon.
• Nasal polyps.