Juvenile polyp

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Juvenile polyp
Diagnosis in short

Juvenile polyp (stomach). H&E stain.

LM

eroded, smooth or lobulated surface, pedunculated, increased lamina propria (LP) +/- edema,

cystically dilated gland, +/-inflammation
LM DDx inflammatory polyp, hyperplastic polyp of the stomach, Cronkhite-Canada syndrome
Site gastrointestinal tract polyps

Syndromes Juvenile polyposis syndrome

Prevalence uncommon
Prognosis benign itself; multiple = marker of increased risk of malignancy
Clin. DDx other GI polyps

Juvenile polyp, abbreviated JP, is a type of hamartomatousgastrointestinal polyp.

In adults, it is known as a retention polyp.

General

  • Uncommon.

May be part of a syndrome:

Gross

  • Mushroom-like shape.

Microscopic

Features:[1][2]

  • Eroded, smooth or lobulated surface.
  • Pedunculated.
  • Increased lamina propria (LP) +/- edema.
  • Cystically dilated gland.
  • Often inflammed.

Mnemonic DIES = dilated glands, increased LP & inflammation of the LP, eroded/smooth surface, stalk.

Notes:

  • May have nuclear changes like those seen in adenomatous polyps.

DDx:

Images

IHC

  • Usually none.

Notes:

  • IHC can be used if it is suspected to have dysplasia (p53, Ki-67).
    • p53 mutations in dysplastic epithelium -- negative stain (normal).

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Polyp, Sigmoid Colon, Polypectomy:
- Juvenile polyp/retention polyp.

Block letters

RECTOSIGMOID POLYP, BIOPSY: 
- RETENTION POLYP. 

See also

References

  1. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 859. ISBN 0-7216-0187-1.
  2. Bronner, MP. (Apr 2003). "Gastrointestinal inherited polyposis syndromes.". Mod Pathol 16 (4): 359-65. doi:10.1097/01.MP.0000062992.54036.E4. PMID 12692201. http://www.nature.com/modpathol/journal/v16/n4/full/3880773a.html.