Sex cord-stromal tumours
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Sex cord-stromal tumours (abbreviated SCSTs) are a group of tumours found in the testis and ovary that arise from the cells that support the germ cells.
They are typically benign, but may be malignant.
Some tumours classically found in the testis are also found in the ovary.
Testicular
- Leydig cell tumour.
- Sertoli cell tumour.
- Primary signet ring stromal tumour.[1]
Ovarian
Arise from gonadal stroma:
Others:
- Unclassified gonadal stromal tumour.[3]
- Microcystic stromal tumour of the ovary.
Mixed
IHC
- Steroidogenic factor 1 (SF1) +ve.[4]
- Calretinin +ve.
- Inhibin A +ve.
- SALL4 -ve.
- Positive in (most) germ cell tumours.
See also
References
- ↑ Michalova K, Michal M, Kazakov DV, Sedivcova M, Hes O, Hadravsky L, Agaimy A, Tretiakova M, Bacchi C, Hartmann A, Kuroda N, Bulimbasic S, Coric M, Antic T, Michal M (September 2017). "Primary signet ring stromal tumor of the testis: a study of 13 cases indicating their phenotypic and genotypic analogy to pancreatic solid pseudopapillary neoplasm". Hum Pathol 67: 85–93. doi:10.1016/j.humpath.2017.07.010. PMID 28739499.
- ↑ 2.0 2.1 Koulouris, CR.; Penson, RT. (Apr 2009). "Ovarian stromal and germ cell tumors.". Semin Oncol 36 (2): 126-36. doi:10.1053/j.seminoncol.2008.12.004. PMID 19332247.
- ↑ Sironi, M.; Santangelo, M.; Pasquinelli, G.; Spinelli, M. (Feb 2001). "[Benign unclassified tumor of the gonadal stroma: importance of alpha-inhibin expression].". Pathologica 93 (1): 50-6. PMID 11294020.
- ↑ "Adult-type granulosa cell tumor of the testis: A case report and review of the literature". Urol Case Rep 50: 102532. September 2023. doi:10.1016/j.eucr.2023.102532. PMC 10445446. PMID 37621390. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445446/.