Difference between revisions of "Lymphocytic mastitis"
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| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = +/-tenderness | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
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| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = breast tumour - possibly malignant | ||
| Tx = | | Tx = | ||
}} | }} | ||
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==General== | ==General== | ||
*If the individual has [[diabetes mellitus]] (DM) it is called ''diabetic mastopathy''.<ref name=pmid12640102>{{Cite journal | last1 = Valdez | first1 = R. | last2 = Thorson | first2 = J. | last3 = Finn | first3 = WG. | last4 = Schnitzer | first4 = B. | last5 = Kleer | first5 = CG. | title = Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. | journal = Mod Pathol | volume = 16 | issue = 3 | pages = 223-8 | month = Mar | year = 2003 | doi = 10.1097/01.MP.0000056627.21128.74 | PMID = 12640102 }}</ref> | *If the individual has [[diabetes mellitus]] (DM) it is called ''diabetic mastopathy''.<ref name=pmid12640102>{{Cite journal | last1 = Valdez | first1 = R. | last2 = Thorson | first2 = J. | last3 = Finn | first3 = WG. | last4 = Schnitzer | first4 = B. | last5 = Kleer | first5 = CG. | title = Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. | journal = Mod Pathol | volume = 16 | issue = 3 | pages = 223-8 | month = Mar | year = 2003 | doi = 10.1097/01.MP.0000056627.21128.74 | PMID = 12640102 }}</ref> | ||
**The diabetes mellitus is long-standing.<ref name=pmid23966831>{{Cite journal | last1 = Alhabshi | first1 = SM. | last2 = Rahmat | first2 = K. | last3 = Westerhout | first3 = CJ. | last4 = Md Latar | first4 = NH. | last5 = Chandran | first5 = PA. | last6 = Aziz | first6 = S. | title = Lymphocytic mastitis mimicking breast carcinoma, radiology and pathology correlation: review of two cases. | journal = Malays J Med Sci | volume = 20 | issue = 3 | pages = 83-7 | month = May | year = 2013 | doi = | PMID = 23966831 }}</ref> | |||
*Rare. | *Rare. | ||
Clinical:<ref name=pmid23966831/> | |||
*+/-Tenderness. | |||
*May mimic malignancy clinically. | |||
==Microscopic== | ==Microscopic== | ||
| Line 52: | Line 57: | ||
*[http://www.webpathology.com/image.asp?n=1&Case=655 Lymphocytic mastitis - low mag. (webpathology.com)]. | *[http://www.webpathology.com/image.asp?n=1&Case=655 Lymphocytic mastitis - low mag. (webpathology.com)]. | ||
*[http://www.webpathology.com/image.asp?case=655&n=2 Lymphocytic mastitis - high mag. (webpathology.com)]. | *[http://www.webpathology.com/image.asp?case=655&n=2 Lymphocytic mastitis - high mag. (webpathology.com)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743988/figure/f3-mjms-20-3-083/ Lymphocytic mastitis (nih.gov)].<ref name=pmid23966831/> | |||
==IHC== | ==IHC== | ||
Revision as of 04:52, 16 February 2014
| Lymphocytic mastitis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | lymphocytic infiltrates (breast lobules, perivascular), enlarged stromal fibroblasts, stromal collagen with keloid-like changes. |
| LM DDx | lymphoma (small cell), diabetic mastopathy (need history) |
| IHC | CD20 > CD3, CD43 -ve |
| Molecular | negative for clonality |
| Site | breast |
|
| |
| Associated Dx | +/-diabetes mellitus (known as diabetic mastopathy) |
| Signs | +/-tenderness |
| Prevalence | rare |
| Prognosis | benign |
| Clin. DDx | breast tumour - possibly malignant |
Lymphocytic mastitis is a rare pathology of the breast.
General
- If the individual has diabetes mellitus (DM) it is called diabetic mastopathy.[1]
- The diabetes mellitus is long-standing.[2]
- Rare.
Clinical:[2]
- +/-Tenderness.
- May mimic malignancy clinically.
Microscopic
Features:[3]
- Lymphocytic infiltrates - key feature:
- Lobules.
- Perivascular.
- Enlarged stromal fibroblasts.
- Stromal collagen with keloid-like changes.
DDx:
- Diabetic mastopathy - if individual has diabetes.
- Primary lymphoma of the breast.
Images
www:
- Lymphocytic mastitis - low mag. (webpathology.com).
- Lymphocytic mastitis - high mag. (webpathology.com).
- Lymphocytic mastitis (nih.gov).[2]
IHC
- B cell predominant (CD20 > CD3).[1]
- B cells CD43 -ve.
Molecular
- Negative clonality studies.
See also
References
- ↑ 1.0 1.1 Valdez, R.; Thorson, J.; Finn, WG.; Schnitzer, B.; Kleer, CG. (Mar 2003). "Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases.". Mod Pathol 16 (3): 223-8. doi:10.1097/01.MP.0000056627.21128.74. PMID 12640102.
- ↑ 2.0 2.1 2.2 Alhabshi, SM.; Rahmat, K.; Westerhout, CJ.; Md Latar, NH.; Chandran, PA.; Aziz, S. (May 2013). "Lymphocytic mastitis mimicking breast carcinoma, radiology and pathology correlation: review of two cases.". Malays J Med Sci 20 (3): 83-7. PMID 23966831.
- ↑ URL: http://www.breastpathology.info/Case_of_the_month/2007/COTM_0707%20discussion.html. Accessed on: 28 November 2010.