Difference between revisions of "Oncometabolite"
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| fumarate hydratase (FH) | | fumarate hydratase (FH) | ||
| [[ | | [[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma|HLRCC syndrome-associated RCC]]<ref name=pmid22866264>{{Cite journal | last1 = Yang | first1 = M. | last2 = Soga | first2 = T. | last3 = Pollard | first3 = PJ. | last4 = Adam | first4 = J. | title = The emerging role of fumarate as an oncometabolite. | journal = Front Oncol | volume = 2 | issue = | pages = 85 | month = | year = 2012 | doi = 10.3389/fonc.2012.00085 | PMID = 22866264 }}</ref> | ||
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| [[IDH mutation|isocitrate dehydrogenase]] (IDH) | | [[IDH mutation|isocitrate dehydrogenase]] (IDH) | ||
| [[Astrocytoma]], [[Oligodendroglioma]]<ref>{{Cite journal | last1 = Hartmann | first1 = C. | last2 = Hentschel | first2 = B. | last3 = Wick | first3 = W. | last4 = Capper | first4 = D. | last5 = Felsberg | first5 = J. | last6 = Simon | first6 = M. | last7 = Westphal | first7 = M. | last8 = Schackert | first8 = G. | last9 = Meyermann | first9 = R. | title = Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. | journal = Acta Neuropathol | volume = 120 | issue = 6 | pages = 707-18 | month = Dec | year = 2010 | doi = 10.1007/s00401-010-0781-z | PMID = 21088844 }}</ref> | | [[Astrocytoma]], [[Oligodendroglioma]]<ref>{{Cite journal | last1 = Hartmann | first1 = C. | last2 = Hentschel | first2 = B. | last3 = Wick | first3 = W. | last4 = Capper | first4 = D. | last5 = Felsberg | first5 = J. | last6 = Simon | first6 = M. | last7 = Westphal | first7 = M. | last8 = Schackert | first8 = G. | last9 = Meyermann | first9 = R. | title = Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. | journal = Acta Neuropathol | volume = 120 | issue = 6 | pages = 707-18 | month = Dec | year = 2010 | doi = 10.1007/s00401-010-0781-z | PMID = 21088844 }}</ref> | ||
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| SDH | | [[Succinate dehydrogenase|SDH]] | ||
| [[Paraganglioma]]<ref>{{Cite journal | last1 = Baysal | first1 = BE. | last2 = Ferrell | first2 = RE. | last3 = Willett-Brozick | first3 = JE. | last4 = Lawrence | first4 = EC. | last5 = Myssiorek | first5 = D. | last6 = Bosch | first6 = A. | last7 = van der Mey | first7 = A. | last8 = Taschner | first8 = PE. | last9 = Rubinstein | first9 = WS. | title = Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. | journal = Science | volume = 287 | issue = 5454 | pages = 848-51 | month = Feb | year = 2000 | doi = | PMID = 10657297 }}</ref> | | [[Paraganglioma]]<ref>{{Cite journal | last1 = Baysal | first1 = BE. | last2 = Ferrell | first2 = RE. | last3 = Willett-Brozick | first3 = JE. | last4 = Lawrence | first4 = EC. | last5 = Myssiorek | first5 = D. | last6 = Bosch | first6 = A. | last7 = van der Mey | first7 = A. | last8 = Taschner | first8 = PE. | last9 = Rubinstein | first9 = WS. | title = Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. | journal = Science | volume = 287 | issue = 5454 | pages = 848-51 | month = Feb | year = 2000 | doi = | PMID = 10657297 }}</ref> | ||
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Latest revision as of 18:12, 22 March 2017
An oncometabolite is a cancer associated protein, often a mutated enzyme.
Examples
| Gene | Cancer |
|---|---|
| fumarate hydratase (FH) | HLRCC syndrome-associated RCC[1] |
| isocitrate dehydrogenase (IDH) | Astrocytoma, Oligodendroglioma[2] |
| SDH | Paraganglioma[3] |
See also
References
- ↑ Yang, M.; Soga, T.; Pollard, PJ.; Adam, J. (2012). "The emerging role of fumarate as an oncometabolite.". Front Oncol 2: 85. doi:10.3389/fonc.2012.00085. PMID 22866264.
- ↑ Hartmann, C.; Hentschel, B.; Wick, W.; Capper, D.; Felsberg, J.; Simon, M.; Westphal, M.; Schackert, G. et al. (Dec 2010). "Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas.". Acta Neuropathol 120 (6): 707-18. doi:10.1007/s00401-010-0781-z. PMID 21088844.
- ↑ Baysal, BE.; Ferrell, RE.; Willett-Brozick, JE.; Lawrence, EC.; Myssiorek, D.; Bosch, A.; van der Mey, A.; Taschner, PE. et al. (Feb 2000). "Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma.". Science 287 (5454): 848-51. PMID 10657297.