Tumour suppressor gene
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A tumour suppressor gene is a gene that acts to protect the organism which it is within from developing cancer.
Examples
| Gene | Syndrome or disease |
|---|---|
| TP53 (p53)[1] | Li-Fraumeni syndrome |
| BRCA1[2] | Familial breast-ovarian cancer 1 |
| RB1[3] | Retinoblastoma |
| VHL[4] | Von Hippel-Lindau disease |
| NF1[5] | Neurofibromatosis type 1 |
| TSC1[6] (hamartin) | Tuberous sclerosis |
| TSC2[6] (tuberin) | Tuberous sclerosis |
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 191170
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 113705
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 614041
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608537
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 613113
- ↑ 6.0 6.1 Johnson, MW.; Kerfoot, C.; Bushnell, T.; Li, M.; Vinters, HV. (Mar 2001). "Hamartin and tuberin expression in human tissues.". Mod Pathol 14 (3): 202-10. doi:10.1038/modpathol.3880286. PMID 11266527.