Tumour suppressor gene

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A tumour suppressor gene is a gene that acts to protect the organism which it is within from developing cancer.

Examples

Gene Syndrome or disease
TP53 (p53)[1] Li-Fraumeni syndrome
BRCA1[2] Familial breast-ovarian cancer 1
RB1[3] Retinoblastoma
VHL[4] Von Hippel-Lindau disease
NF1[5] Neurofibromatosis type 1
TSC1[6] (hamartin) Tuberous sclerosis
TSC2[6] (tuberin) Tuberous sclerosis

See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 191170
  2. Online 'Mendelian Inheritance in Man' (OMIM) 113705
  3. Online 'Mendelian Inheritance in Man' (OMIM) 614041
  4. Online 'Mendelian Inheritance in Man' (OMIM) 608537
  5. Online 'Mendelian Inheritance in Man' (OMIM) 613113
  6. 6.0 6.1 Johnson, MW.; Kerfoot, C.; Bushnell, T.; Li, M.; Vinters, HV. (Mar 2001). "Hamartin and tuberin expression in human tissues.". Mod Pathol 14 (3): 202-10. doi:10.1038/modpathol.3880286. PMID 11266527.