Retinoblastoma

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Retinoblastoma
Diagnosis in short

Retinoblastoma. (WC)

LM small round cell tumour, Flexner-Wintersteiner rosettes, +/-Homer-Wright rosettes, mitoses (common), +/-necrosis, +/-calcifications
LM DDx retinocytoma, other small round cell tumours
Gross white, solid, friable
Site eye

Prevalence rare

Retinoblastoma is a malignant tumour the of the eye.

General

Gross

  • White, solid.
  • Patterns:
    • Endophytic - grow into the vitreous cavity.
    • Exophytic - grow toward choroid.
    • Mixed - components of endophytic and exophytic.

Note:

  • Tumour is extremely friable.

Image

Microscopic

Features:

  • Small round cell tumour:
    • Scant cytoplasm.
  • Flexner-Wintersteiner rosette - key feature.
    • Rosette with empty centre (donut hole).[2]
  • +/-Homer-Wright rosette.[3]
    • Circular rosette with neuropil at the centre.[2]
  • Mitoses - common.
  • +/-Necrosis.
  • +/-Calcification.

DDx:

  • Retinocytoma (retinoma) - benign counterpart of retinoblastoma.

Notes:

  • DDx of Flexner-Wintersteiner rosette includes:
    • Pineoblastoma.
    • Medulloepithelioma.

Images

www

See also

References

  1. Lohmann D (2010). "Retinoblastoma". Adv. Exp. Med. Biol. 685: 220–7. PMID 20687510.
  2. 2.0 2.1 Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  3. WH. 14 March 2011.