Succinate dehydrogenase

SDH immunostain in a muscle biopsy with denervation atrophy.

Succinate dehydrogenase, abbreviated SDH, is an enzyme complex in the citric acid cycle and electron transport chain. It is localized to the mitochondria.

Immunostain

• It is used to look for mitochondrial disease.
• Loss of staining is pathologic.

Associated pathology

Mutations in SDH genes are associated with:

• Paraganglioma.
• Pheochromocytoma.
• Succinate dehydrogenase renal cell carcinoma.
• Gastrointestinal stromal tumour.

See also

• Immunohistochemistry.
• Neuromuscular pathology.
• Carney-Stratakis syndrome.