Papillary thyroid carcinoma: Difference between revisions

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BRAF
 
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| IHC        = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve
| IHC        = HBME-1 +ve, [[CK19]] +ve, Galectin-3 +ve, thyroglobulin +ve, TTF-1 +ve
| EM        =
| EM        =
| Molecular  =
| Molecular  = BRAF mutation - commonly
| IF        =
| IF        =
| Gross      =
| Gross      =
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Images:
Images:
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=2008080217023776 PTC follicular variant (surgicalpathologyatlas.com)].
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=2008080216593186 PTC follicular variant (surgicalpathologyatlas.com)].
*[http://www.thyroidcancercanada.org/userfiles/images/Follicular_slide.jpg PTC follicular variant (thyroidcancercanada.org)].<ref>URL: [http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en http://www.thyroidcancercanada.org/types-of-thyroid-cancer.php?lang=en]. Accessed on: 9 January 2013.</ref>


===Papillary thyroid carcinoma cribriform-morular variant===
===Papillary thyroid carcinoma cribriform-morular variant===
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===IHC===
===IHC===
Thyroid versus something else:
Thyroid versus something else:
*Thyroglobulin +ve.
*Thyroglobulin +ve.<ref name=pmid23637102>{{Cite journal  | last1 = Sathiyamoorthy | first1 = S. | last2 = Maleki | first2 = Z. | title = Cytomorphologic overlap of differentiated thyroid carcinoma and lung adenocarcinoma and diagnostic value of TTF-1 and TGB on cytologic material. | journal = Diagn Cytopathol | volume = 42 | issue = 1 | pages = 5-10 | month = Jan | year = 2014 | doi = 10.1002/dc.22997 | PMID = 23637102 }}</ref>
*TTF-1 ([[thyroid transcription factor-1]]) +ve.
*TTF-1 ([[thyroid transcription factor-1]]) +ve.
*CD15 +ve.{{fact}}
*CD15 +ve.{{fact}}
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===Molecular===
===Molecular===
*Currently not widely used in a diagnostic context.
*BRAF mutation.<ref name=pmid35670964>{{cite journal |authors=Lam AK |title=Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification |journal=Methods Mol Biol |volume=2534 |issue= |pages=1–15 |date=2022 |pmid=35670964 |doi=10.1007/978-1-0716-2505-7_1 |url=}}</ref>


====Tabular summary====
====Tabular summary====
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