Noninvasive follicular thyroid neoplasm with papillary-like nuclear features

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Noninvasive follicular thyroid neoplasm with papillary like-nuclear features is a proposed term for encapsulated thyroid tumours with papillary-like features. It is abbreviated NIFTP[1] and pronounced nift-pee.

The term NIFTP is a compromise of sorts and probably best described as a contrived acronym that can easily be pronounced; NIFTNPLNF isn't catchy or easy to pronounce.

If one wants to make it a backronym, NIFTP could be noninvasive follicular tumour, papillary-like.


  • Encapsulated thyroid tumours with nuclear papillary-like features without invasion have a good prognosis, and labelling them as cancer is probably not unwarranted.[2]
  • Can only be diagnosed on excisional specimens where the entire tumour capsule is sampled.[citation needed]


Features of NIFTP:[3]

  • Major features - all required for diagnosis:
    • Nuclear features of papillary thyroid carcinoma - 2 or 3 of the following:
      1. Nuclear membranes changes (irregular membrane contours, nuclear grooves, nuclear pseudoinclusions).
      2. Size and shape changes (enlargement, elongation, overlapping).
      3. Chromatin changes (clearing, chromatin margination, glass-like appearance).
    • Encapsulated or well-demarcated.
    • Follicular pattern.
  • Minor features:
    • Intratumoural fibrosis, eosinophilic and paucicellular.
    • Clefting of follicules from surrounding stroma.
    • Multinucleated cells.
    • Dark colloid.

Features that exclude the diagnosis of NIFTP:[3]



See also


  1. URL: Accessed on: 26 March 2016.
  2. Ganly, I.; Wang, L.; Tuttle, RM.; Katabi, N.; Ceballos, GA.; Harach, HR.; Ghossein, R. (May 2015). "Invasion rather than nuclear features correlates with outcome in encapsulated follicular tumors: further evidence for the reclassification of the encapsulated papillary thyroid carcinoma follicular variant.". Hum Pathol 46 (5): 657-64. doi:10.1016/j.humpath.2015.01.010. PMID 25721865.
  3. 3.0 3.1 URL: Accessed on: 5 April 2016.

External links