Difference between revisions of "Adenoid cystic carcinoma of the breast"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Breast_AdenoidCysticCarcinoma_MP_CTR.jpg | |||
| Width = | |||
| Caption = Adenoid cystic carcinoma of the breast. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = cribriform [[DCIS]], [[invasive cribriform carcinoma of the breast]], [[collagenous spherulosis]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[breast grossing]] | |||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = surgery | |||
}} | |||
'''Adenoid cystic carcinoma of the breast''' is a rare type of [[breast cancer]] that is similar to a relatively common tumour of the [[salivary gland]]. | '''Adenoid cystic carcinoma of the breast''' is a rare type of [[breast cancer]] that is similar to a relatively common tumour of the [[salivary gland]]. | ||
It is also known as '''breast adenoid cystic carcinoma''', abbreviated '''BACC'''.<ref name=pmid16203286>{{Cite journal | last1 = Crisi | first1 = GM. | last2 = Marconi | first2 = SA. | last3 = Makari-Judson | first3 = G. | last4 = Goulart | first4 = RA. | title = Expression of c-kit in adenoid cystic carcinoma of the breast. | journal = Am J Clin Pathol | volume = 124 | issue = 5 | pages = 733-9 | month = Nov | year = 2005 | doi = 10.1309/61MV-ENEK-5EJ7-JKGF | PMID = 16203286 }}</ref> | |||
==General== | ==General== | ||
| Line 8: | Line 42: | ||
==Microscopic== | ==Microscopic== | ||
:See: ''[[Adenoid cystic carcinoma]]'' article. | :See: ''[[Adenoid cystic carcinoma]]'' article. | ||
DDx: | DDx: | ||
*Cribriform [[DCIS]]. | *Cribriform [[DCIS]]. | ||
*Invasive cribriform carcinoma. | *[[Invasive cribriform carcinoma of the breast]]. | ||
*[[Collagenous spherulosis]]. | *[[Collagenous spherulosis]]. | ||
==Images== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Breast AdenoidCysticCarcinoma 2 LP CTR.jpg|Breast Adenoid Cystic Carcinoma - low power (SKB) | Image:Breast AdenoidCysticCarcinoma 2 LP CTR.jpg|Breast Adenoid Cystic Carcinoma - low power (SKB) | ||
| Line 38: | Line 67: | ||
Image:Breast AdenoidCysticCarcinoma SolidType 2 14BR***.jpg|Breast Adenoid Cystic Carcinoma - Solid Type - high power (SKB) | Image:Breast AdenoidCysticCarcinoma SolidType 2 14BR***.jpg|Breast Adenoid Cystic Carcinoma - Solid Type - high power (SKB) | ||
</gallery> | </gallery> | ||
www: | |||
*[http://path.upmc.edu/cases/case140.html Adenoid cystic carcinoma of the breast (upmc.edu)]. | |||
==IHC== | |||
*One of the 'good prognosis' triple negative breast cancers - ER, PR and HER2 negative.<ref name=pmid16258515>{{Cite journal | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref> | |||
*Basal-like breast cancer - p63 and CK5/6 positive.<ref name=pmid16258515>{{Cite journal | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref> | |||
CD117 positive<ref name=pmid16258515>{{Cite journal | last1 = Azoulay | first1 = S. | last2 = Laé | first2 = M. | last3 = Fréneaux | first3 = P. | last4 = Merle | first4 = S. | last5 = Al Ghuzlan | first5 = A. | last6 = Chnecker | first6 = C. | last7 = Rosty | first7 = C. | last8 = Klijanienko | first8 = J. | last9 = Sigal-Zafrani | first9 = B. | title = KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome. | journal = Mod Pathol | volume = 18 | issue = 12 | pages = 1623-31 | month = Dec | year = 2005 | doi = 10.1038/modpathol.3800483 | PMID = 16258515 }}</ref> | |||
==Other Resources== | ==Other Resources== | ||
| Line 50: | Line 86: | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category: | [[Category:Invasive breast cancer]] | ||
Latest revision as of 11:35, 8 September 2016
| Adenoid cystic carcinoma of the breast | |
|---|---|
| Diagnosis in short | |
 Adenoid cystic carcinoma of the breast. H&E stain. | |
| LM DDx | cribriform DCIS, invasive cribriform carcinoma of the breast, collagenous spherulosis |
| Grossing notes | breast grossing |
| Staging | breast cancer staging |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | very rare |
| Prognosis | good |
| Treatment | surgery |
Adenoid cystic carcinoma of the breast is a rare type of breast cancer that is similar to a relatively common tumour of the salivary gland.
It is also known as breast adenoid cystic carcinoma, abbreviated BACC.[1]
General
- Like tumour of the salivary gland.
- Very rare <0.1% of breast malignancies.[2]
- Good prognosis.[2]
Microscopic
- See: Adenoid cystic carcinoma article.
DDx:
Images
Breast Adenoid Cystic Carcinoma - low power (SKB)
Breast Adenoid Cystic Carcinoma - medium power (SKB)
Breast Adenoid Cystic Carcinoma - medium power (SKB)
Breast Adenoid Cystic Carcinoma - medium power (SKB)
Breast Adenoid Cystic Carcinoma - medium power (SKB)
Breast Adenoid Cystic Carcinoma - medium power (SKB)
Breast Adenoid Cystic Carcinoma - medium power (SKB)
Breast Adenoid Cystic Carcinoma - high power (SKB)
Breast Adenoid Cystic Carcinoma - high power (SKB)
Breast Adenoid Cystic Carcinoma - high power (SKB)
Breast Adenoid Cystic Carcinoma - high power (SKB)
Breast - Adenoid Cystic Carcinoma - Solid Type - Low power (SKB)
Breast - Adenoid Cystic Carcinoma - Solid Type - medium power - Aggregates of basaloid cells without tubule or cyst formation. (SKB)
Breast - Adenoid Cystic Carcinoma - Solid Type - High power (SKB)
Breast Adenoid Cystic Carcinoma - Solid Type - high power (SKB)
.jpg)
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.jpg)
www:
IHC
- One of the 'good prognosis' triple negative breast cancers - ER, PR and HER2 negative.[3]
- Basal-like breast cancer - p63 and CK5/6 positive.[3]
CD117 positive[3]
Other Resources
Pathology Outlines [1]
See also
References
- ↑ Crisi, GM.; Marconi, SA.; Makari-Judson, G.; Goulart, RA. (Nov 2005). "Expression of c-kit in adenoid cystic carcinoma of the breast.". Am J Clin Pathol 124 (5): 733-9. doi:10.1309/61MV-ENEK-5EJ7-JKGF. PMID 16203286.
- ↑ 2.0 2.1 Boujelbene, N.; Khabir, A.; Boujelbene, N.; Jeanneret Sozzi, W.; Mirimanoff, RO.; Khanfir, K. (Dec 2011). "Clinical review - Breast adenoid cystic carcinoma.". Breast. doi:10.1016/j.breast.2011.11.006. PMID 22154460.
- ↑ 3.0 3.1 3.2 Azoulay, S.; Laé, M.; Fréneaux, P.; Merle, S.; Al Ghuzlan, A.; Chnecker, C.; Rosty, C.; Klijanienko, J. et al. (Dec 2005). "KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome.". Mod Pathol 18 (12): 1623-31. doi:10.1038/modpathol.3800483. PMID 16258515.