Difference between revisions of "Plasma cell"

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[[Image:Plasmacell.jpg|thumb|right|A plasma cell.]]
The '''plasma cell''' is white blood cell that produces antibodies.   
The '''plasma cell''' is white blood cell that produces antibodies.   


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Features:
Features:
*Ovoid intermediate-small cell size ~ 12 micrometers:
*Ovoid intermediate-small cell size ~ 12 micrometers:
**Cells slightly larger than [[red blood cell]]s and [[neurophil]]s.
**Cells slightly larger than [[red blood cell]]s and [[neutrophil]]s.
*Eccentric nucleus.
*Eccentric nucleus.
**Nucleus usu. hugs the cell membrane.
**Nucleus usu. hugs the cell membrane.
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***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.
***Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.


Images:
Note:
*[http://commons.wikimedia.org/wiki/File:Plasmacytoma_ultramini1.jpg Plasma cells (WC)].
*Multinucleation is not a worisome feature.{{fact}}
 
===Images===
<gallery>
Image: Multinucleated plasma cell -- high mag.jpg | Plasma cells - high mag.
Image: Multinucleated plasma cell -- very high mag.jpg | Plasma cells - very high mag.
Image: Multinucleated plasma cell -- extremely high mag.jpg | Plasma cells - extremely high mag.
Image: Chronic_gastritis_--_very_high_mag.jpg | Plasma cells in [[chronic gastritis]] - very high mag.
</gallery>
<gallery>
Image:Plasmacytoma_ultramini1.jpg | Plasma cells in a plasmacytoma. (WC)
</gallery>


==Neoplasia==
==Neoplasia==
Line 23: Line 35:
==IHC==
==IHC==
*CD38 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref>
*CD38 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref>
*CD138 +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref>
*[[CD138]] +ve.<ref name=Ref_WMSP554>{{Ref WMSP|554}}</ref>


Others:
Others:
*CD19 -ve.
*CD19 -ve.
*CD20 -ve
*CD20 -ve
*CD56 -ve.
*[[CD56]] -ve.
 
==Lesions where plasma cells are important==
===Selected lesions with plasma cells===
Neoplasms:
*[[Plasma cell neoplasms]].
*[[Lymphoplasmacytic lymphoma]] - '''not''' truly plasma cells.
*[[Inflammatory myofibroblastic tumour]] (inflammatory pseudotumour).
*Classical [[Hodgkin lymphoma]].
 
Inflammatory conditions:
*[[Inflammatory bowel disease]] - esp. at crypt base.
*[[Primary biliary cholangitis]].
*[[Chronic gastritis]].
*[[Plasma cell balanitis]] (Zoon balanitis).
*[[Plasma cell vulvitis]] (Zoon vulvitis).
*[[Plasma cell deciduitis]] (chronic deciduitis).
 
Infectious:
*[[Syphilis]].
*[[Chancroid]].
*[[Granuloma inguinale]].
*[[Lymphogranuloma venereum]].
 
===Plasma cells are absent===
*[[Common variable immunodeficiency]].<ref name=pmid20629103>{{cite journal |author=Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L |title=Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease |journal=Inflamm Bowel Dis |volume= |issue= |pages= |year=2010 |month=July |pmid=20629103 |doi=10.1002/ibd.21376 |url=}}</ref>


==See also==
==See also==
*[[Basics]].
*[[Red blood cell]].
*[[Red blood cell]].
*[[Neutrophil]].
*[[Plasma cell neoplasms]].
*[[IgG4-related systemic disease]].
*[[Plasmacytoid urothelial carcinoma]].


==References==
==References==
{{Reflist|1}}
{{Reflist|1}}


[[Category:Haematopathology]]
[[Category:Basics]]

Latest revision as of 21:02, 30 September 2021

A plasma cell.

The plasma cell is white blood cell that produces antibodies.

Microscopic

Features:

  • Ovoid intermediate-small cell size ~ 12 micrometers:
  • Eccentric nucleus.
    • Nucleus usu. hugs the cell membrane.
    • "Clock-face" chromatin pattern.
      • Small dots symmetrically rim the nuclear membrane - like the numbers on a clock.
  • Abundant cytoplasm.
    • Nucleus-to-cytoplasm ratio ~1:2
    • Perinuclear hof (prominent Gogli apparatus).
      • Pale perinuclear crescentic - may be up to the size of the nucleus in active plasma cells.

Note:

Images

  • Plasma cells - high mag.

  • Plasma cells - very high mag.

  • Plasma cells - extremely high mag.

  • Plasma cells in chronic gastritis - very high mag.

  • Plasma cells in a plasmacytoma. (WC)

Neoplasia

Main article: Plasma cell neoplasms

Neoplasms derived from plasma cell are called plasma cell neoplasms.

IHC

Others:

  • CD19 -ve.
  • CD20 -ve
  • CD56 -ve.

Lesions where plasma cells are important

Selected lesions with plasma cells

Neoplasms:

Inflammatory conditions:

Infectious:

Plasma cells are absent

See also

References

  1. ↑ 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 554. ISBN 978-0781765275.
  2. ↑ Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L (July 2010). "Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease". Inflamm Bowel Dis. doi:10.1002/ibd.21376. PMID 20629103.
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