Difference between revisions of "Adenocarcinoma"

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'''Adenocarcinoma''' is a form of [[cancer]] that arises from glandular tissue.  It can arise in many sites.
[[Image:Lung adenocarcinoma - pleural fluid -- very high mag.jpg|thumb|right|250px|Adenocarcinoma (lung). Pleural fluid specimen. [[Pap stain]]. (WC)]]
[[Image:Colorectal adenocarcinoma cytology low mag.jpg|thumb|right|250px|Adenocarcinoma (colorectal). [[Field stain]]. (WC)]]
[[Image:Colorectal adenocarcinoma -- high mag.jpg|thumb|right|250px|[[Colorectal adenocarcinoma]]. [[H&E stain]]. (WC)]]
'''Adenocarcinoma''' is a form of [[cancer]] that arises from glandular tissue.  Adenocarcinoma can arise in many sites.


==Microscopic==
'''Adenocarcinoma [[not otherwise specified]]''', also '''adenocarcinoma NOS''', is a non-specific malignant diagnosis that without further information is ''not'' very useful for treatment decisions. 
 
=Types of adenocarcinoma=
==Site specific==
Below is an incomplete list of adenocarcinomas.
===Gastrointestinal pathology===
====Esophagus====
*[[Esophageal adenocarcinoma]].
 
====Stomach====
*[[Gastric adenocarcinoma]].
 
====Duodenum====
*[[Adenocarcinoma of the duodenum]].
 
=====Ampulla of Vater=====
*[[Ampullary adenocarcinoma]].
 
====Pancreas====
*[[Pancreatic ductal adenocarcinoma]].
 
====Gallbladder====
*[[Gallbladder adenocarcinoma]].
 
====Colon and rectum====
*[[Colorectal adenocarcinoma]].
 
===Other===
====Lung====
*[[Adenocarcinoma of the lung]].
 
====Salivary gland====
*[[Polymorphous low-grade adenocarcinoma]].
*[[Basal cell adenocarcinoma]].
 
===Gynecologic pathology===
====Ovary====
*[[Ovarian clear cell adenocarcinoma]].
*[[Mucinous adenocarcinoma of the ovary]].
 
====Endometrium====
*[[Endometrioid endometrial adenocarcinoma]].
 
====Cervix====
*[[Endocervical adenocarcinoma]].
*[[Villoglandular adenocarcinoma of the cervix]].
*[[Minimal deviation adenocarcinoma of the uterine cervix]].
 
===Genitourinary pathology===
====Prostate====
*[[Prostatic adenocarcinoma]], not otherwise specified.
*[[Prostatic ductal adenocarcinoma]].
*[[PIN-like prostatic ductal adenocarcinoma]].
 
====Testis====
*[[Adenocarcinoma of the rete testis]].
 
====Urinary bladder====
*[[Adenocarcinoma of the urinary bladder]].
*[[Urachal adenocarcinoma]].
 
==General type==
*[[Clear cell adenocarcinoma]].
*[[Mucinous adenocarcinoma]].
 
=Microscopic (generic)=
Features:
Features:
*Gland forming - round/ovoid/tubular spaces.
*Gland forming - round/ovoid/tubular spaces.
*Eccentric nucleus.
*Eccentric nucleus.
*Moderate cytoplasm.
*Moderate cytoplasm +/- vacuoles.
*+/-Prominent nucleolus.
*+/-Prominent nucleolus.
*+/-[[Nuclear atypia]] - dependent on type/site.
DDx:
*Carcinoma (poorly differentiated).
*[[Sarcoma]], esp. [[epithelioid sarcomas]].
*Benign glands.
**[[Endometriosis]].
**[[Endosalpingiosis]].
**[[Adenomyosis]].


===Grading===
===Grading===
Special grading systems exists based on the primary site:
*[[Nottingham grade]] for [[invasive breast cancer]]
*[[Prostate cancer grading|WHO grade groups]] for [[prostate cancer]].
*Others.
Adenocarcinomas are often graded by their glandular component:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf]. Accessed on: 6 April 2012.</ref>
Adenocarcinomas are often graded by their glandular component:<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf]. Accessed on: 6 April 2012.</ref>
*Grade 1: >95% of tumour glandular.
*Grade 1: >95% of tumour glandular.
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*Grade 3: <50% of tumour glandular.
*Grade 3: <50% of tumour glandular.


==References==
=See also=
*[[Carcinoma]].
*[[Adenocarcinoma in situ]].
*[[Pathologic fracture]].
 
=References=
{{Reflist|1}}
{{Reflist|1}}


[[Category:Basics]]
[[Category:Basics]]
[[Category:Diagnosis]]

Latest revision as of 14:44, 8 November 2019

Adenocarcinoma (lung). Pleural fluid specimen. Pap stain. (WC)
Adenocarcinoma (colorectal). Field stain. (WC)
Colorectal adenocarcinoma. H&E stain. (WC)

Adenocarcinoma is a form of cancer that arises from glandular tissue. Adenocarcinoma can arise in many sites.

Adenocarcinoma not otherwise specified, also adenocarcinoma NOS, is a non-specific malignant diagnosis that without further information is not very useful for treatment decisions.

Types of adenocarcinoma

Site specific

Below is an incomplete list of adenocarcinomas.

Gastrointestinal pathology

Esophagus

Stomach

Duodenum

Ampulla of Vater

Pancreas

Gallbladder

Colon and rectum

Other

Lung

Salivary gland

Gynecologic pathology

Ovary

Endometrium

Cervix

Genitourinary pathology

Prostate

Testis

Urinary bladder

General type

Microscopic (generic)

Features:

  • Gland forming - round/ovoid/tubular spaces.
  • Eccentric nucleus.
  • Moderate cytoplasm +/- vacuoles.
  • +/-Prominent nucleolus.
  • +/-Nuclear atypia - dependent on type/site.

DDx:

Grading

Special grading systems exists based on the primary site:

Adenocarcinomas are often graded by their glandular component:[1]

  • Grade 1: >95% of tumour glandular.
  • Grade 2: 50-95% of tumour glandular.
  • Grade 3: <50% of tumour glandular.

See also

References

  1. ↑ URL: http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Esophagus_11protocol.pdf. Accessed on: 6 April 2012.
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