Nuclear atypia, also atypical nuclei, is an abnormal change of the cell nucleus.
Nuclear atypia is often seen in malignancy; however, it may be seen in benign conditions - notably inflammation. Also, nuclear atypia in endocrine organs (known as endocrine atypia) is considered normal.
Cancer with no appreciable or minimal nuclear atypia
An incomplete list:
- Low grade papillary urothelial carcinoma.
- Some adenocarcinomas of the upper gastrointestinal tract, e.g. gallbladder adenocarcinoma, stomach adenocarcinoma, ductal adenocarcinoma of the pancreas.
- Invasive lobular carcinoma.
- Verrucous squamous cell carcinoma.
- Some malignant melanomas.