High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate

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High-grade prostatic intraepithelial neoplasia-like ductal adenocarcinoma of the prostate, abbreviated PIN-like adenocarcinoma, is an uncommon type of prostate cancer that histomorphologically mimics high-grade prostatic intraepithelial neoplasia (HGPIN).

General

Microscopic

Features:[1][3]

  • Columnar cells with pseudostratified nuclei.
    • Non-columnar cells with round nuclei also described.
  • Simple glands: flat, tufted or micropapillary.

Note:

DDx:

Image

See also

References

  1. 1.0 1.1 Hameed, O.; Humphrey, PA. (Jul 2006). "Stratified epithelium in prostatic adenocarcinoma: a mimic of high-grade prostatic intraepithelial neoplasia.". Mod Pathol 19 (7): 899-906. doi:10.1038/modpathol.3800601. PMID 16607376.
  2. Lee, TK.; Miller, JS.; Epstein, JI. (Jun 2010). "Rare histological patterns of prostatic ductal adenocarcinoma.". Pathology 42 (4): 319-24. doi:10.3109/00313021003767314. PMID 20438402.
  3. 3.0 3.1 Tavora, F.; Epstein, JI. (Jul 2008). "High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases.". Am J Surg Pathol 32 (7): 1060-7. doi:10.1097/PAS.0b013e318160edaf. PMID 18496142.