Difference between revisions of "Drug toxicity"

From Libre Pathology
Jump to navigation Jump to search
(start)
 
 
(16 intermediate revisions by the same user not shown)
Line 3: Line 3:
This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems.
This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems.


=General principles=
A drug/toxin reaction should be considered if there is:
# Ingestion/exposure.
# An appropriate temporal relation.
# An empirical correlation between the drug/toxin and the pattern.
#* Worsening with re-challenge.
#* Improvement with removal of exposure.
#* Pathologic pattern matches with toxin.
#* Drug/toxin detected within individual.
=Site specific=
==Liver drug toxicity==
*[[Drug-induced liver disease]].
==Stomach==
*[[Reactive gastropathy]].
==Small bowel==
*[[Small bowel diaphragm disease]].
=Specific drugs=
==Sodium polystyrene sulfonate==
==Sodium polystyrene sulfonate==
[[AKA]] ''Kayexalate''
:[[AKA]] ''Kayexalate'' (trade name).
===General===
===General===
*Used to treat hyperkalemia.
*Used to treat hyperkalemia.
Line 12: Line 33:
*Can cause focal [[necrosis]].
*Can cause focal [[necrosis]].


Image:
====Image====
*[http://commons.wikimedia.org/wiki/File:Cecal_adenocarcinoma.jpg Kayexalate crystals and adenocarcinoma (WC)].
<gallery>
Image:Cecal_adenocarcinoma.jpg | Kayexalate crystals and adenocarcinoma. (WC)
</gallery>
 
==Proton pump inhibitor==
{{Main|Proton pump inhibitor effect}}
 
==Nonsteroidal anti-inflammatory drugs==
{{Main|Nonsteroidal anti-inflammatory drugs}}
 
==Oral contraceptive pill==
{{Main|Oral contraceptive pill}}
 
==Minocycline==
*[[Minocycline associated thyroid pigmentation]].
 
==Spironolactone==
*[[Spironolactone bodies]].


==See also==
=See also=
*[[Drug-induced liver toxicity]].
*[[Basics]].


==References==
=References=
{{Reflist|1}}
{{Reflist|1}}


[[Category:Stuff]]
[[Category:Stuff]]

Latest revision as of 03:20, 22 March 2018

Drug toxicity, also drug reaction, in pathology is often a diagnosis of exclusion. Few drugs leave a distinctive histomorphologic pattern.

This article covers a few of the distinctive histomorphologic pattern and links to other articles that deal with specific organ systems.

General principles

A drug/toxin reaction should be considered if there is:

  1. Ingestion/exposure.
  2. An appropriate temporal relation.
  3. An empirical correlation between the drug/toxin and the pattern.
    • Worsening with re-challenge.
    • Improvement with removal of exposure.
    • Pathologic pattern matches with toxin.
    • Drug/toxin detected within individual.

Site specific

Liver drug toxicity

Stomach

Small bowel

Specific drugs

Sodium polystyrene sulfonate

AKA Kayexalate (trade name).

General

  • Used to treat hyperkalemia.

Microscopic

Features:[1]

Image

Proton pump inhibitor

Nonsteroidal anti-inflammatory drugs

Oral contraceptive pill

Minocycline

Spironolactone

See also

References