Difference between revisions of "Ki-67"
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*Usually nuclear staining. | *Usually nuclear staining. | ||
Membranous staining pattern | ===Membranous staining pattern=== | ||
*[[Pneumocytoma]] has membranous pattern.<ref name=pmid23030396>{{Cite journal | last1 = Kim | first1 = BH. | last2 = Bae | first2 = YS. | last3 = Kim | first3 = SH. | last4 = Jeong | first4 = HJ. | last5 = Hong | first5 = SW. | last6 = Yoon | first6 = SO. | title = Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. | journal = APMIS | volume = 121 | issue = 2 | pages = 105-10 | month = Feb | year = 2013 | doi = 10.1111/j.1600-0463.2012.02945.x | PMID = 23030396 }}</ref> | *[[Pneumocytoma]] has membranous pattern.<ref name=pmid23030396>{{Cite journal | last1 = Kim | first1 = BH. | last2 = Bae | first2 = YS. | last3 = Kim | first3 = SH. | last4 = Jeong | first4 = HJ. | last5 = Hong | first5 = SW. | last6 = Yoon | first6 = SO. | title = Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. | journal = APMIS | volume = 121 | issue = 2 | pages = 105-10 | month = Feb | year = 2013 | doi = 10.1111/j.1600-0463.2012.02945.x | PMID = 23030396 }}</ref> | ||
*[[Hyalinizing trabecular tumour]].<ref name=pmid17525638>{{Cite journal | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref> | *[[Hyalinizing trabecular tumour]].<ref name=pmid17525638>{{Cite journal | last1 = Leonardo | first1 = E. | last2 = Volante | first2 = M. | last3 = Barbareschi | first3 = M. | last4 = Cavazza | first4 = A. | last5 = Dei Tos | first5 = AP. | last6 = Bussolati | first6 = G. | last7 = Papotti | first7 = M. | title = Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact? | journal = Appl Immunohistochem Mol Morphol | volume = 15 | issue = 2 | pages = 220-3 | month = Jun | year = 2007 | doi = 10.1097/01.pai.0000213122.66096.f0 | PMID = 17525638 }}</ref> | ||
Revision as of 16:54, 2 July 2017
| Ki-67 | |
|---|---|
| Immunostain in short | |
 Ki-67 staining in an anaplastic astrocytoma. | |
| Use | typical carcinoid versus atypical carcinoid), grading (gastrointestinal neuroendocrine tumours) |
| Normal staining pattern | nuclear staining, membranous pattern in pneumocytoma |
Ki-67 is a very commonly used immunostain that mirror proliferation.
General
- Marker of proliferation.
- Usually nuclear staining.
Membranous staining pattern
- Pneumocytoma has membranous pattern.[1]
- Hyalinizing trabecular tumour.[2]
See also
References
- ↑ Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.
- ↑ Leonardo, E.; Volante, M.; Barbareschi, M.; Cavazza, A.; Dei Tos, AP.; Bussolati, G.; Papotti, M. (Jun 2007). "Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?". Appl Immunohistochem Mol Morphol 15 (2): 220-3. doi:10.1097/01.pai.0000213122.66096.f0. PMID 17525638.