Uterine carcinosarcoma

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Uterine carcinosarcoma
Diagnosis in short

Carcinosarcoma. H&E stain.

LM biphasic tumour: (1) malignant epithelial component (carcinoma), (2) mesenchymal differentiation ("sarcoma")
LM DDx undifferentiated endometrial sarcoma, adenosarcoma of the uterus, endometrial carcinomas
Site uterus - see uterine tumours

Clinical history +/-previous radiation exposure
Prevalence uncommon
Prognosis poor

Uterine carcinosarcoma, also known as malignant mixed muellerian tumour (abbreviated MMMT), is an uncommon malignant uterine tumour.

General

Microscopic

Features:[7]

DDx:

Images

www:

IHC

Features:

  • CD10 +ve/-ve (16 +ve of 27[8]).
  • SMA -ve/+ve (11 +ve of 27[8]).
  • Desmin -ve/+ve (9 +ve of 27[8]).
  • p53 -ve (8 +ve of 27[8]).

See also

References

  1. Cantrell, LA.; Blank, SV.; Duska, LR. (Jun 2015). "Uterine carcinosarcoma: A review of the literature.". Gynecol Oncol 137 (3): 581-588. doi:10.1016/j.ygyno.2015.03.041. PMID 25805398.
  2. Artioli, G.; Wabersich, J.; Ludwig, K.; Gardiman, MP.; Borgato, L.; Garbin, F. (Apr 2015). "Rare uterine cancer: carcinosarcomas. Review from histology to treatment.". Crit Rev Oncol Hematol 94 (1): 98-104. doi:10.1016/j.critrevonc.2014.10.013. PMID 25468677.
  3. D'Angelo, E.; Prat, J. (Jan 2010). "Uterine sarcomas: a review.". Gynecol Oncol 116 (1): 131-9. doi:10.1016/j.ygyno.2009.09.023. PMID 19853898.
  4. Lopez-Garcia, MA.; Palacios, J. (Nov 2010). "Pathologic and molecular features of uterine carcinosarcomas.". Semin Diagn Pathol 27 (4): 274-86. PMID 21309261.
  5. Ivy, JJ.; Unger, JB.. "Malignant mixed mullerian sarcomas of the uterus--the LSUHSC Shreveport experience.". J La State Med Soc 156 (6): 324-6. PMID 15688674.
  6. Callister, M.; Ramondetta, LM.; Jhingran, A.; Burke, TW.; Eifel, PJ. (Mar 2004). "Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome.". Int J Radiat Oncol Biol Phys 58 (3): 786-96. doi:10.1016/S0360-3016(03)01561-X. PMID 14967435.
  7. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 428. ISBN 978-0781765275.
  8. 8.0 8.1 8.2 8.3 Koivisto-Korander, R.; Butzow, R.; Koivisto, AM.; Leminen, A. (Jun 2011). "Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: expression and prognostic importance of ten different markers.". Tumour Biol 32 (3): 451-9. doi:10.1007/s13277-010-0138-1. PMID 21161468.