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Difference between revisions of "Invasive breast cancer"
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→Characteristics of the subtypes
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*Desmin -ve. | *Desmin -ve. | ||
*EMA -ve. (???) | *EMA -ve. (???) | ||
==Apocrine carcinoma== | |||
===General=== | |||
*Need >=90% apocrine morphology.<ref name=Ref_BP217>{{Ref BP|217}}</ref> | |||
===Microscopic=== | |||
Features:<ref name=Ref_BP217>{{Ref BP|217}}</ref> | |||
*Prominent [[nucleoli]]. | |||
*Abundant granular eosinophilic cytoplasm. | |||
===IHC=== | |||
*Smaller tumours classically:<ref name=pmid16045781>{{Cite journal | last1 = Honma | first1 = N. | last2 = Takubo | first2 = K. | last3 = Akiyama | first3 = F. | last4 = Sawabe | first4 = M. | last5 = Arai | first5 = T. | last6 = Younes | first6 = M. | last7 = Kasumi | first7 = F. | last8 = Sakamoto | first8 = G. | title = Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast. | journal = Histopathology | volume = 47 | issue = 2 | pages = 195-201 | month = Aug | year = 2005 | doi = 10.1111/j.1365-2559.2005.02181.x | PMID = 16045781 }}</ref> | |||
*AR +ve. | |||
*GCDFP-15 +ve. | |||
Usually:<ref name=Ref_BP217>{{Ref BP|217}}</ref> | |||
*ER -ve. | |||
*PR -ve. | |||
=Grading breast cancer= | =Grading breast cancer= | ||