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Difference between revisions of "Invasive breast cancer"
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→Sentinel lymph node biopsy: more
(→Sentinel lymph node biopsy: more) |
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Notes: | Notes: | ||
* | *If there is no palpable disease, there is '''no''' mortality benefit from axillary lymph node dissection, i.e. positive axillary lymph nodes can be left in situ without affecting outcome.<ref>{{cite journal |author=Giuliano AE, Hunt KK, Ballman KV, ''et al.'' |title=Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial |journal=JAMA |volume=305 |issue=6 |pages=569–75 |year=2011 |month=February |pmid=21304082 |doi=10.1001/jama.2011.90 |url=}}</ref> | ||
**This does not negate the fact that a positive sentinel LN biopsy (vs. negative sentinel LN biopsy) portends a poorer prognosis. | **This does not negate the fact that a positive sentinel LN biopsy (vs. negative sentinel LN biopsy) portends a poorer prognosis. | ||
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Some hospitals use: | Some hospitals use: | ||
*CAM5.2 (LMWK) - to look for isolated tumour cells and small lymph node metstases. | *CAM5.2 (LMWK) - to look for isolated tumour cells and small lymph node metstases. | ||
==Missed macrometastases== | |||
The effect is small of missed macrometastases.<ref name=pmid21247310>PMID 21247310.</ref> | |||
==Trivia== | ==Trivia== | ||