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Difference between revisions of "P16"
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Image:Consistent with HPV-associated SCC - p16 -- high mag.jpg | c/w HPV-assoc. SCC - p16 - high mag. (WC/Nephron) | Image:Consistent with HPV-associated SCC - p16 -- high mag.jpg | c/w HPV-assoc. SCC - p16 - high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
===Penile cancer=== | |||
*p16 is considered surrogate for HPV and ''block-type positivity'' is considered indicative of HPV.<ref name=pmid36221864>{{cite journal |authors=Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB |title=WHO 2022 classification of penile and scrotal cancers: updates and evolution |journal=Histopathology |volume=82 |issue=4 |pages=508–520 |date=March 2023 |pmid=36221864 |doi=10.1111/his.14824 |url=}}<ref> | |||
*An older meta-analysis shows that p16 staining criteria are not firmly established. | |||
<pre> | |||
The p16 staining is patchy (~10% of tumour) and moderate. The 2022 WHO Classification describes "block-type positivity" as being relevant; as such, the case is interpreted as p16 NEGATIVE. | |||
HPV testing will be requested and the findings reported in an addendum. | |||
</pre> | |||
==Positive== | ==Positive== | ||
*[[Squamous cell carcinoma]] - esp. [[cervical SCC]], anal SCC, penile SCC, [[HPV-associated head and neck SCC]]. | *[[Squamous cell carcinoma]] - esp. [[cervical SCC]], anal SCC, penile SCC, [[HPV-associated head and neck SCC]]. | ||