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Difference between revisions of "POEMS syndrome"
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→Diagnostic criteria
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''Mandatory:'' | ''Mandatory:'' | ||
# Polyneuropathy (typically demyelinating) | # Polyneuropathy (typically demyelinating). | ||
# Monoclonal plasma cell proliferation (usually lambda) | # Monoclonal plasma cell proliferation (usually lambda). | ||
''Major:'' | ''Major:'' | ||
# [[Castleman disease]] | # [[Castleman disease]] | ||
# Sclerotic bone lesions | # Sclerotic bone lesions. | ||
# Vascular endothelial growth factor elevation | # Vascular endothelial growth factor elevation. | ||
''Minor:'' | ''Minor:'' | ||
# Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) | # Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy). | ||
# Extravascular volume overload | # Extravascular volume overload. | ||
# Endocrinopathy | # Endocrinopathy. | ||
# | # Skin changes. | ||
# Papilloedema | # Papilloedema. | ||
# Thrombocytosis/polycythemia | # Thrombocytosis/polycythemia. | ||
POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]]. | POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]]. | ||