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Difference between revisions of "POEMS syndrome"
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*Skin changes. | *Skin changes. | ||
Diagnostic criteria | ==Diagnostic criteria== | ||
Requires both mandatory criteria and at least one each from major and minor criteria:<ref name=pmid31012139>{{cite journal |authors=Dispenzieri A |title=POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management |journal=Am. J. Hematol. |volume=94 |issue=7 |pages=812–827 |date=July 2019 |pmid=31012139 |doi=10.1002/ajh.25495 |url=}}</ref> | |||
''Mandatory:'' | ''Mandatory:'' | ||
# Polyneuropathy (typically demyelinating) | |||
# Monoclonal plasma cell proliferation (usually lambda) | |||
''Major:'' | ''Major:'' | ||
# [[Castleman disease]] | |||
# Sclerotic bone lesions | |||
# Vascular endothelial growth factor elevation | |||
''Minor:'' | ''Minor:'' | ||
# Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy) | |||
# Extravascular volume overload | |||
# Endocrinopathy | |||
# Sking changes | |||
# Papilloedema | |||
# Thrombocytosis/polycythemia | |||
POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]]. | POEMS syndrome is unusual in causing osteosclerotic bone deposits, so-called osteosclerotic myeloma, in contrast to the lytic lesions seen in more conventional [[plasma cell myeloma]]. | ||