POEMS syndrome

From Libre Pathology
Jump to navigation Jump to search

POEMS syndrome is a constellation of findings, best thought of as a paraneoplastic syndrome due to clonal plasma cells:[1]

  • Polyneuropathy.
  • Organomegaly.
  • Endocrinopathy.
  • M-protein.
  • Skin changes.

Diagnostic criteria

Requires both mandatory criteria and at least one each from major and minor criteria:[2]


  1. Polyneuropathy (typically demyelinating).
  2. Monoclonal plasma cell proliferation (usually lambda).


  1. Castleman disease
  2. Sclerotic bone lesions.
  3. Vascular endothelial growth factor elevation.


  1. Organomegaly (splenomegaly, hepatomegaly or lymphadenopathy).
  2. Extravascular volume overload.
  3. Endocrinopathy.
  4. Skin changes.
  5. Papilloedema.
  6. Thrombocytosis/polycythemia.


See also


  1. Yuri T, Yamazaki F, Takasu K, Shikata N, Tsubura A (June 2008). "Glomeruloid hemangioma". Pathol. Int. 58 (6): 390–5. doi:10.1111/j.1440-1827.2008.02241.x. PMID 18477219.
  2. Dispenzieri A (July 2019). "POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management". Am. J. Hematol. 94 (7): 812–827. doi:10.1002/ajh.25495. PMID 31012139.
  3. González-Guerra E, Haro MR, Fariña MC, Martín L, Manzarbeitia L, Requena L (October 2009). "Glomeruloid haemangioma is not always associated with POEMS syndrome". Clin. Exp. Dermatol. 34 (7): 800–3. doi:10.1111/j.1365-2230.2008.02997.x. PMID 19077091.