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Difference between revisions of "Microsatellite instability in colorectal cancer"
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Microsatellite instability in colorectal cancer (view source)
Revision as of 20:44, 23 October 2017
, 20:44, 23 October 2017→Molecular
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#MLH3. | #MLH3. | ||
#MSH3. | #MSH3. | ||
Small subset of cases is caused by mutations in EPCAM, | |||
*EPCAM mutations lead to epigenetic silencing of MSH2 | Additional notes: | ||
*Small subset of cases is caused by mutations in EPCAM, a gene adjacent to MSH2. | |||
**EPCAM mutations lead to epigenetic silencing of MSH2.<ref name=pmid25701956>{{Cite journal | last1 = Yamamoto | first1 = H. | last2 = Imai | first2 = K. | title = Microsatellite instability: an update. | journal = Arch Toxicol | volume = 89 | issue = 6 | pages = 899-921 | month = Jun | year = 2015 | doi = 10.1007/s00204-015-1474-0 | PMID = 25701956 }}</ref> | |||
==IHC== | ==IHC== | ||