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Difference between revisions of "Course:Introduction to Neuropathology"
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Course:Introduction to Neuropathology (view source)
Revision as of 13:44, 2 October 2015
, 13:44, 2 October 2015+ case 2
Jensflorian (talk | contribs) (→Day 2: sample 1) |
Jensflorian (talk | contribs) (+ case 2) |
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File:Neuropathology case IX.jpg | [[ATRX]] | File:Neuropathology case IX.jpg | [[ATRX]] | ||
File:Neuroparthology case IX 0125.jpg | [[IDH1]] | File:Neuroparthology case IX 0125.jpg | [[IDH1]] | ||
File:Neuroparthology case IX 0125.jpg | panCK | |||
</gallery> | </gallery> | ||
[[Glioblastoma]] is a pleomorphic astroglial tumor with endothelial proliferations and necrosis. As expected by a malignant tumor, the number of proliferating cells (MIB-1) is high. The tumour cells often stain for GFAP. There is no ATRX loss and the IDH1 R132H mutation is absent (negative staining). | [[Glioblastoma]] is a pleomorphic astroglial tumor with endothelial proliferations and necrosis. As expected by a malignant tumor, the number of proliferating cells (MIB-1) is high. The tumour cells often stain for GFAP. There is no ATRX loss and the IDH1 R132H mutation is absent (negative staining). | ||
{{hidden|Other language: German| Glioblastome sind pleomorphe astrogliale Tumore mit Gefäßproliferaten und Nekrosen. Entsprechend einem malignen Tumor ist die Anzahl der proliferierenden Zellen (MIB-1) hoch. Die Tumorzellen markieren sich für GFAP. Es besteht kein Verlust von ATRX und die IDH1 R132H Mutationsfärbung ist negativ. | |||
}} | |||
<gallery> | |||
File:Oligodendroglioma1 low mag.jpg | [[H&E]] | |||
File: x | GFAP | |||
File:Neuropathology case II 04.jpg | MIB-1 | |||
File:Neuroparthology case IX 0125.jpg | ATRX | |||
File:IDH1 R132H in anaplastic ologodendroglioma.jpg | [[IDH1]] | |||
File:Neuropathology case IX.jpg | panCK | |||
</gallery> | |||
[[Oligodendroglioma]] is a diffuse geowing glial tumour with clear cell morphology. In WHO grade II the MIB-1 proliferation index is rather low. GFAP stains the neuropil background and minigemistocytes (if present). There is no ATRX loss. The vast majority of oligodendrogliomas stain positively for IDH1 R132H mutation. | |||