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Difference between revisions of "Parathyroid adenoma"
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Parathyroid adenoma (view source)
Revision as of 03:28, 11 September 2015
, 03:28, 11 September 2015tweak
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| Caption = Chief cell parathyroid adenoma (left of image) and unremarkable parathyroid gland (right of image). [[H&E stain]]. (WC) | | Caption = Chief cell parathyroid adenoma (left of image) and unremarkable parathyroid gland (right of image). [[H&E stain]]. (WC) | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = proliferation of parathyroid cells (chief cells, oxyphils or both) usually lacking adipose tissue, +/-rimmed by normal parathyroid gland, lack of destructive invasion of surround structures, lack of metastatic disease | ||
| Subtypes = | | Subtypes = chief cell, oxyphil, mixed | ||
| LMDDx = [[parathyroid hyperplasia]], [[parathyroid carcinoma]], [[lymph node]], [[thyroid gland]] | | LMDDx = [[parathyroid hyperplasia]], [[parathyroid carcinoma]], [[lymph node]], [[thyroid gland]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = Ki-67 low | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Grossing = | | Grossing = | ||
| Site = [[parathyroid gland]] ([[head and neck pathology|neck]]/[[mediastinum]]) | | Site = [[parathyroid gland]] ([[head and neck pathology|neck]]/[[mediastinum]]) | ||
| Assdx = | | Assdx = [[nephrolithiasis|renal stones]], osteitis fibrosa cystica | ||
| Syndromes = [[MEN 1|multiple endocrine neoplasia 1]], [[MEN 2A|multiple endocrine neoplasia 2A]] | | Syndromes = [[MEN 1|multiple endocrine neoplasia 1]], [[MEN 2A|multiple endocrine neoplasia 2A]] | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = constipation | ||
| Symptoms = | | Symptoms = bone pain, abdominal pain, lethargy, fatigue, memory loss | ||
| Prevalence = | | Prevalence = | ||
| Bloodwork = increased parathyroid hormone, serum calcium increased | | Bloodwork = increased parathyroid hormone, serum calcium increased | ||
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| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = depression, psychosis, delirium, coma, ataxia | ||
| ClinDDx = nodule (lymph node, other tumours), hyperparathyroidism ([[parathyroid hyperplasia]], [[parathyroid carcinoma]]), DDx of [[hypercalcemia]] | | ClinDDx = nodule (lymph node, other tumours), hyperparathyroidism ([[parathyroid hyperplasia]], [[parathyroid carcinoma]]), DDx of [[hypercalcemia]] | ||
| Tx = | | Tx = surgical excision | ||
}} | }} | ||
'''Parathyroid adenoma''' is a common benign pathology of the [[parathyroid gland]]. | '''Parathyroid adenoma''' is a common benign pathology of the [[parathyroid gland]]. | ||