653
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Difference between revisions of "Invasive breast cancer"
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→Microscopic
(→IHC) |
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Clear spaces/clefting around | *Small micropapillary tufts of tumour cells or tubuloalveolar structures. | ||
*Central '''avascular''' stromal core. | |||
*Clear spaces/clefting around the small clusters of tumor cells - '''diffuse/through-out the tumour''' - '''key feature'''. | |||
**Described as "small clusters of tumour lying within dilated vascular channel-like spaces".<ref name=pmid20444748>{{Cite journal | last1 = Yamaguchi | first1 = R. | last2 = Tanaka | first2 = M. | last3 = Kondo | first3 = K. | last4 = Yokoyama | first4 = T. | last5 = Kaneko | first5 = Y. | last6 = Yamaguchi | first6 = M. | last7 = Ogata | first7 = Y. | last8 = Nakashima | first8 = O. | last9 = Kage | first9 = M. | title = Characteristic morphology of invasive micropapillary carcinoma of the breast: an immunohistochemical analysis. | journal = Jpn J Clin Oncol | volume = 40 | issue = 8 | pages = 781-7 | month = Aug | year = 2010 | doi = 10.1093/jjco/hyq056 | PMID = 20444748 | URL = http://jjco.oxfordjournals.org/content/40/8/781.long }}</ref> | **Described as "small clusters of tumour lying within dilated vascular channel-like spaces".<ref name=pmid20444748>{{Cite journal | last1 = Yamaguchi | first1 = R. | last2 = Tanaka | first2 = M. | last3 = Kondo | first3 = K. | last4 = Yokoyama | first4 = T. | last5 = Kaneko | first5 = Y. | last6 = Yamaguchi | first6 = M. | last7 = Ogata | first7 = Y. | last8 = Nakashima | first8 = O. | last9 = Kage | first9 = M. | title = Characteristic morphology of invasive micropapillary carcinoma of the breast: an immunohistochemical analysis. | journal = Jpn J Clin Oncol | volume = 40 | issue = 8 | pages = 781-7 | month = Aug | year = 2010 | doi = 10.1093/jjco/hyq056 | PMID = 20444748 | URL = http://jjco.oxfordjournals.org/content/40/8/781.long }}</ref> | ||
* | **Can appear sponge like or swiss cheese like. | ||
* | |||
*Abundant finely granular cytoplasm. | *Abundant finely granular cytoplasm. | ||
*Mucin cytoplasmic but not in the surrounding clear spaces. | *Mucin cytoplasmic but not in the surrounding clear spaces. | ||
*Nuclear atypia is moderate or severe. | *Nuclear atypia is moderate or severe. | ||
*Mixed(micropapillary + other) histological pattern common. | *Mixed(micropapillary + other) histological pattern common. | ||
*Can show psamomma bodies or other calcifications. | |||
DDX | DDX | ||