653
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Difference between revisions of "Invasive breast cancer"
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→Microscopic
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Lesion confined to a | *Lesion confined to a cyst. | ||
**May have a thick fibrous capsule | **May have a thick fibrous capsule | ||
**The involved space | **The involved space is ''not'' lined by myoepithelial cells. | ||
*Loss of myoepithelial cells | *The cyst contains an abnormal epithelial proliferation with cribriform, solid or papillary architecture. | ||
*Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | **Loss of myoepithelial cells within the epithelial proliferation is a '''key feature'''. | ||
**Scattered large cells with pale eosinophilic cytoplasm may be observed<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | |||
</ref>. | </ref>. | ||
**These cells are so-called globoid cells or clear cells and are immunoreactive for GCDFP-15. | ***These cells are so-called globoid cells or clear cells and are immunoreactive for GCDFP-15. | ||
**They should not be mistaken for myoepithelial cells. | ***They should not be mistaken for myoepithelial cells. | ||
*Neoplastic epithelial cells: | **Neoplastic epithelial cells: | ||
**[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]]. | ***[[Nuclear atypia]] - including: nucleoli, [[nuclear pleomorphism]]. | ||
** | |||
IHC: | |||
*Calponin/p63/SMA/CK5-6 | |||
**Loss of myoepithelial cells within the tumor. | |||
**Loss of myoepithelial cells at the cyst wall. | |||
*ER - Homogenous staining of the epithelial proliferation. | |||
Photos: | Photos: | ||