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Difference between revisions of "Invasive breast cancer"
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DDx: | DDx<ref>{{Cite journal | last1 = Collins | first1 = LC. | last2 = Schnitt | first2 = SJ. | title = Papillary lesions of the breast: selected diagnostic and management issues. | journal = Histopathology | volume = 52 | issue = 1 | pages = 20-9 | month = Jan | year = 2008 | doi = 10.1111/j.1365-2559.2007.02898.x | PMID = 18171414 }} | ||
</ref><ref>{{Cite journal | last1 = Pathmanathan | first1 = N. | last2 = Albertini | first2 = AF. | last3 = Provan | first3 = PJ. | last4 = Milliken | first4 = JS. | last5 = Salisbury | first5 = EL. | last6 = Bilous | first6 = AM. | last7 = Byth | first7 = K. | last8 = Balleine | first8 = RL. | title = Diagnostic evaluation of papillary lesions of the breast on core biopsy. | journal = Mod Pathol | volume = 23 | issue = 7 | pages = 1021-8 | month = Jul | year = 2010 | doi = 10.1038/modpathol.2010.81 | PMID = 20473278 }}</ref>: | |||
*[[Intraductal papilloma]]. | *[[Intraductal papilloma]]. | ||
**Absent or scant stroma favors papillary carcinoma over papilloma. | |||
**Is there a single cell or dual cell population in the lesion? | |||
***ER staining will be heterologous in a benign lesion. | |||
***If myoepithelial markers are negative within the lesion then malignancy is favoured. | |||
*[[Papillary ductal carcinoma in situ]] | |||
**Papillary DCIS shows myoepithelial cells (calponin/p63/SMA +ve) at the periphery of the involved spaces | |||
**Papillary intracystic carcinoma does not show myoepithelial cells at the periphery of the involved spaces | |||
*Invasive carcinoma arising in association with papillary intracystic carcinoma | |||
**Epithelial entrapment in the encysting fibrous tissue should not be interpreted as invasion. | |||
**Carcinoma must be seen in the breast tissue outside the encysting fibrous tissue. | |||
*[[Adenoid cystic carcinoma of the breast]] | |||
**The solid variant looks basaloid - solid adenoid cystic carcinoma or a 'basal-like' carcinoma should be considered in these cases. | |||
Notes | |||
*Adequately and carefully sample the specimen to exclude an invasive component. | |||
*Report only the size of the invasive component (if present) to prevent over-estimation of tumor stage. | |||
===IHC=== | ===IHC=== | ||