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Difference between revisions of "Invasive breast cancer"
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→Breast IHC
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**Increased incidence in some populations - African-Americans, young women | **Increased incidence in some populations - African-Americans, young women | ||
**Sporadic basal-like cancers do not have a BRCA1 mutation but may have a dysfunctional BRCA1 pathway. | **Sporadic basal-like cancers do not have a BRCA1 mutation but may have a dysfunctional BRCA1 pathway. | ||
**p53 mutations are frequent | |||
*This molecular group includes a variety of morphologic phenotypes including: | *This molecular group includes a variety of morphologic phenotypes including: | ||
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***The tumours that do not metastasise have a better prognosis than other types of breast carcinoma. | ***The tumours that do not metastasise have a better prognosis than other types of breast carcinoma. | ||
***Tumours with early metastasis may behave more aggressively | ***Tumours with early metastasis may behave more aggressively | ||
****Hematogenous spread -greater tendency to metastasise to visceral sites associated with poorer prognosis (such as lung and brain) instead of to nodes and bone | ****Hematogenous spread -greater tendency to metastasise to visceral sites associated with poorer prognosis (such as lung and brain) instead of to nodes and bone. | ||
**Many have a complete response to chemotherapy and survival rates similar to typical breast cancer | |||
**Non-complete response to chemotherapy is associated with low survival at 5 years. | |||
Other sources | |||
Minireview: Basal-Like Breast Cancer: From Molecular Profiles to Targeted Therapies <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035993/> | |||
== Triple Negative Breast Carcinoma ==<ref>{{Cite journal | last1 = Badve | first1 = S. | last2 = Dabbs | first2 = DJ. | last3 = Schnitt | first3 = SJ. | last4 = Baehner | first4 = FL. | last5 = Decker | first5 = T. | last6 = Eusebi | first6 = V. | last7 = Fox | first7 = SB. | last8 = Ichihara | first8 = S. | last9 = Jacquemier | first9 = J. | title = Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. | journal = Mod Pathol | volume = 24 | issue = 2 | pages = 157-67 | month = Feb | year = 2011 | doi = 10.1038/modpathol.2010.200 | PMID = 21076464 }}</ref> | == Triple Negative Breast Carcinoma ==<ref>{{Cite journal | last1 = Badve | first1 = S. | last2 = Dabbs | first2 = DJ. | last3 = Schnitt | first3 = SJ. | last4 = Baehner | first4 = FL. | last5 = Decker | first5 = T. | last6 = Eusebi | first6 = V. | last7 = Fox | first7 = SB. | last8 = Ichihara | first8 = S. | last9 = Jacquemier | first9 = J. | title = Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists. | journal = Mod Pathol | volume = 24 | issue = 2 | pages = 157-67 | month = Feb | year = 2011 | doi = 10.1038/modpathol.2010.200 | PMID = 21076464 }}</ref> | ||