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Difference between revisions of "Invasive breast cancer"
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→HER2 scoring
(→IHC) |
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| Line 243: | Line 243: | ||
*Evaluated on the invasive component. | *Evaluated on the invasive component. | ||
===HER2 scoring=== | ===HER2 scoring=== | ||
Immunohistochemical based testing:<ref name= | Immunohistochemical based testing:<ref name=pmid24382093>{{Cite journal | last1 = Rakha | first1 = EA. | last2 = Starczynski | first2 = J. | last3 = Lee | first3 = AH. | last4 = Ellis | first4 = IO. | title = The updated ASCO/CAP guideline recommendations for HER2 testing in the management of invasive breast cancer: a critical review of their implications for routine practice. | journal = Histopathology | volume = 64 | issue = 5 | pages = 609-15 | month = Apr | year = 2014 | doi = 10.1111/his.12357 | PMID = 24382093 }}</ref><ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/breast_biomarker_template.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/breast_biomarker_template.pdf]. Accessed on: October 7, 2014.</ref> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
! Score | ! Score | ||
| Line 253: | Line 253: | ||
|- | |- | ||
| '''0''' | | '''0''' | ||
| nil | | nil/barely visible | ||
| '''<=10%''' | | '''<=10%''' | ||
| '''incomplete''' | | '''incomplete''' | ||
| Line 267: | Line 267: | ||
|- | |- | ||
| '''2+''' | | '''2+''' | ||
| weak-to-moderate '' | | weak-to-moderate | ||
| ''' | | '''>10%''' | ||
| '''incomplete''' | |||
| Needs [[SISH]] or [[FISH]] | |||
| ~10% † | |||
|- | |||
| '''2+''' | |||
| intense | |||
| '''<10%''' | |||
| '''complete''' | | '''complete''' | ||
| Needs [[SISH]] or [[FISH]] | | Needs [[SISH]] or [[FISH]] | ||
| ~10% | | ~10% † | ||
|- | |- | ||
| '''3+''' | | '''3+''' | ||
| intense | | intense staining | ||
| '''> | | '''>10%''' ‡ | ||
| '''complete''' | | '''complete''' | ||
| HER2 blocker | | HER2 blocker | ||
| Line 286: | Line 293: | ||
*SISH = silver [[in situ hybridization]]. | *SISH = silver [[in situ hybridization]]. | ||
*FISH = fluorescence in situ hybridization. | *FISH = fluorescence in situ hybridization. | ||
*† Together approximately 10%. | |||
*‡ The cut point was 10%, changed to 30% and then changed back to 10%.<ref name=pmid24382093/> | |||
ISH based testing:<ref name=Lester3_87>{{Ref Lester3|87}}</ref> | ISH based testing:<ref name=Lester3_87>{{Ref Lester3|87}}</ref> | ||