Difference between revisions of "Invasive breast cancer"

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Invasive breast cancer (view source)

Revision as of 15:48, 27 May 2014

1,823 bytes removed ,  15:48, 27 May 2014
→‎Familial breast cancer: split out
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==Familial breast cancer==
==Familial breast cancer==
===Syndromes associated with breast cancer===
{{Main|Hereditary breast cancer}}
{| class="wikitable sortable"
! Gene
! Syndrome
! Other cancers
! Notes
|-
| BRCA1
| Familial breast and ovarian cancer<ref name=omim113705>{{OMIM|113705}}</ref>
| male breast, ovarian, prostate, pancreas, fallopian tube
| younger individuals vis-à-vis BRCA2
|-
| BRCA2
| Familial breast and ovarian cancer 2<ref name=omim600185>{{OMIM|600185}}</ref>
| male breast, ovarian, prostate, pancreas, stomach, melanoma, gallbladder, bile duct, pharynx
| older individuals vis-à-vis BRCA1
|-
| TP53 (p53)
| [[Li-Fraumeni syndrome]] ([[AKA]] ''SBLA syndrome'')
| [[sarcoma]]s, brain cancer, larynx, lung, leukemia, [[adrenal cortical carcinoma]]
| often present in childhood
|-
| CHEK2
| [[Li-Fraumeni syndrome]] (variant)
| see ''p53''
| -
|-
| STK11
| [[Peutz-Jeghers syndrome]]
| breast cancer, GI cancer, [[Sertoli cell tumour]], [[Granulosa cell tumour]], [[SCTAT]]
| characteristic GI [[hamartoma]]s, mucocutaneous pigmentation
|-
| PTEN
| [[Cowden syndrome]]
| breast, thyroid (PTC), endometrial, renal, colorectal
| -
|-
| CDH1
| Familial diffuse gastric cancer<ref name=omim192090>{{OMIM|192090}}</ref>
| [[invasive lobular carcinoma]], gastric [[signet ring cell carcinoma]]
| -
|-
|}
 
===BRCA1 and BRCA2===
BRCA1 vs. BRCA2:<ref name=Ref_PBoD8_1078>{{Ref PBoD8|1078}}</ref>
{| class="wikitable sortable"
! Gene
! Age
! Histology
! Other cancers
|-
| BRCA1
| younger
| worse types, e.g. triple negative breast ca.
| uterine tube
|-
| BRCA2
| older
| sporadic types
| stomach, melanoma, gallbladder, bile duct, pharynx
|}
 
Types of cancer associated with both BRCA1 and BRCA2 - ''male OPP'':
*'''Male''' breast, '''o'''varian, '''p'''rostate, '''p'''ancreas.
 
How to remember types of cancer associated with BRCA2 - ''PUM'':
*'''P'''harynx, '''u'''pper GI (stomach, gallbladder, biliary), '''m'''elanoma.


=Breast IHC=
=Breast IHC=
Michael
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